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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

features

Research: Exercise reduces risk of disease by changing DNA

Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen

Published in Health Club Management 2021 issue 8
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
The beneficial changes to the brain – prompted by exercise – protect against the development of various diseases due to signals release by muscles into the bloodstream

Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease by driving epigenetic changes in the body.

The finding comes from a study by the University of Copenhagen which reveals how exercise remodels the DNA in skeletal muscle, so new signals are established to keep the body healthy.

While it’s known that regular physical exercise decreases the risk of virtually all chronic illnesses, the mechanisms at play have not been fully understood. The discovery suggests the beneficial effects of physical exercise may – in part – come from the epigenetic changes they prompt.

The research team studied a group of healthy young men through a six-week endurance exercise programme.

A biopsy of participants’ thigh muscle was collected before and after the exercise intervention and examined to see whether changes in the epigenetic signature of their DNA occurred as a result of training.

Structure of muscle
Scientists discovered that after completing the endurance training programme, the structure of many enhancers in the skeletal muscle had been altered.

By connecting these enhancers to series of genetic databases, they discovered that many of the regulated enhancers have already been identified by researchers as ‘hotspots’ that have been associated with human disease. These beneficial changes – prompted by exercise – are thought to protect against the development of various diseases.

Brain benefits
The researchers also found that exercise benefited organs that are distant from muscle, such as the brain – they speculate that these additional benefits might have come about as a result of signals released by muscles into the bloodstream.

Epigenetic links
Kristine Williams, lead author of the study, said: “Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.”

The research was published in the journal Molecular Metabolism.

Professor Romain Barrès, senior author, added: “Our findings provide a mechanism for the known beneficial effects of exercise.

“By connecting each enhancer with a gene, we further provide a list of direct targets that could mediate this effect.”

More: www.HCMmag.com/epigenetic

https://www.leisureopportunities.co.uk/images/2021/26667_490676.jpg
Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease
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Catalogue Gallery
Click on a catalogue to view it online
Directory
Exercise equipment
Matrix Fitness: Exercise equipment
Architects/designers
Zynk Design Consultants: Architects/designers
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Management software
Premier Software Solutions: Management software
trade associations
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Property & Tenders
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Diary dates
01-03 Feb 2022
Coventry Building Society Arena, Coventry, United Kingdom
Diary dates
07-10 Apr 2022
Exhibition Centre , Cologne, Germany
Diary dates
15-16 Jun 2022
ExCeL London, London, United Kingdom
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates

features

Research: Exercise reduces risk of disease by changing DNA

Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen

Published in Health Club Management 2021 issue 8
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
The beneficial changes to the brain – prompted by exercise – protect against the development of various diseases due to signals release by muscles into the bloodstream

Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease by driving epigenetic changes in the body.

The finding comes from a study by the University of Copenhagen which reveals how exercise remodels the DNA in skeletal muscle, so new signals are established to keep the body healthy.

While it’s known that regular physical exercise decreases the risk of virtually all chronic illnesses, the mechanisms at play have not been fully understood. The discovery suggests the beneficial effects of physical exercise may – in part – come from the epigenetic changes they prompt.

The research team studied a group of healthy young men through a six-week endurance exercise programme.

A biopsy of participants’ thigh muscle was collected before and after the exercise intervention and examined to see whether changes in the epigenetic signature of their DNA occurred as a result of training.

Structure of muscle
Scientists discovered that after completing the endurance training programme, the structure of many enhancers in the skeletal muscle had been altered.

By connecting these enhancers to series of genetic databases, they discovered that many of the regulated enhancers have already been identified by researchers as ‘hotspots’ that have been associated with human disease. These beneficial changes – prompted by exercise – are thought to protect against the development of various diseases.

Brain benefits
The researchers also found that exercise benefited organs that are distant from muscle, such as the brain – they speculate that these additional benefits might have come about as a result of signals released by muscles into the bloodstream.

Epigenetic links
Kristine Williams, lead author of the study, said: “Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.”

The research was published in the journal Molecular Metabolism.

Professor Romain Barrès, senior author, added: “Our findings provide a mechanism for the known beneficial effects of exercise.

“By connecting each enhancer with a gene, we further provide a list of direct targets that could mediate this effect.”

More: www.HCMmag.com/epigenetic

https://www.leisureopportunities.co.uk/images/2021/26667_490676.jpg
Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease
Latest News
Anthony Hamilton, the father of F1 racing driver Lewis Hamilton, is launching a fitness equipment ...
Latest News
The pandemic has had an "unprecedented" impact on physical activity levels in England, with 1 ...
Latest News
The first énergie Fitness club has opened in Spain as part of a push for ...
Latest News
A global innovation competition has been launched to find ways to encourage and support more ...
Latest News
Xponential Fitness has acquired Body Fit Training in a deal worth US$44m. The deal takes ...
Latest News
Exercise has been highlighted as a crucial weapon in cancer patients’ battle against the disease. ...
Latest News
The global health and fitness industry is returning to a busy programme of live trade ...
Latest News
Matrix and Intelivideo have signed a strategic partnership, which will see Intelivideo's fitness content integrated ...
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Nadine Dorries, the recently appointed secretary of state for digital, culture, media and sport at ...
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Mindbody has announced it's buying ClassPass, the consumer wellness subscription service that enables people to ...
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Tanni Grey-Thompson has outlined her vision on how the physical activity sector can play "the ...
Featured supplier news
Featured supplier news: Are traditional gyms going to war with smart gyms?
CEO of Orbit4, Daniel Jones, says: “There’s no reason traditional gyms and smart gyms can’t live in harmony. With a little reorganisation and education, there’s a really bright future for all gyms.”
Featured supplier news
Featured supplier news: Technogym awarded “Supplier of the year” at ukactive awards 2021
The best in class of the physical activity sector have been revealed at the ukactive Awards 2021.
Featured operator news
Featured operator news: Everyone Active generates £342m in social value
Award-winning leisure operator Everyone Active generated £342million in social value at its sites across the country in 2019/20.
Featured operator news
Featured operator news: Sporting heroes to officially open £22 million redevelopment at Everyone Active centre
A £22 million redevelopment project will be unveiled at Grange Paddocks Leisure Centre, as part of the official launch of the state-of-the-art centre.
Company profiles
Company profile: RISE Fitness Franchise
RISE is a brand-new franchise created to fill an emerging gap. Outdoor workouts have become ...
Company profiles
Company profile: Quoox
With more than 200 integrated features, Quoox is confident there is a solution for every ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Exercise equipment
Matrix Fitness: Exercise equipment
Architects/designers
Zynk Design Consultants: Architects/designers
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Management software
Premier Software Solutions: Management software
trade associations
International SPA Association - iSPA: trade associations
Spa software
SpaBooker: Spa software
Red Light Therapy
 Red Light Rising: Red Light Therapy
Fitness equipment
Precor: Fitness equipment
Salt therapy products
Himalayan Source: Salt therapy products
Independent service & maintenance
Servicesport UK Limited: Independent service & maintenance
Property & Tenders
Welwyn Garden City
Welwyn Hatfield Borough Council
Property & Tenders
Newport, Shropshire
Lilleshall Sports Academy
Property & Tenders
Diary dates
01-03 Feb 2022
Coventry Building Society Arena, Coventry, United Kingdom
Diary dates
07-10 Apr 2022
Exhibition Centre , Cologne, Germany
Diary dates
15-16 Jun 2022
ExCeL London, London, United Kingdom
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates
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