You may not have heard of NAD+ before – but this tiny molecule is fast becoming a star in the worlds of wellness and beauty.

NAD+ (nicotinamide adenine dinucleotide) is often called “the longevity molecule" because it is an essential coenzyme that fuels cellular energy, repairs DNA, regulates metabolism and even influences epigenetic activity – the process by which genes are switched on or off. Unfortunately, NAD+ levels naturally decline with age and even more so during peri-menopause and menopause.

Reduced NAD+ results in lower levels of collagen, slower skin repair and faster, visible signs of ageing.

Dr Shahzadi Harper, a trailblazer in midlife women’s health, has seen first-hand the difference that supplemental NAD+ can make: “For women going through the hormonal shifts of perimenopause, NAD+ can be a real game-changer – supporting energy, focus, metabolism and skin vitality. At The Harper Clinic, we often recommend NAD+ injection pens to help women improve energy, hormonal balance, mood and skin health – either alone or alongside HRT.”

Now, Swissline is offering women a chance to boost NAD+ topically via 360° Collagen Night Concentrate, winner of the Tatler UK 2025 Beauty Awards for Best in Mature Skin.

At the heart of the formula is RejuveNad, a groundbreaking ingredient developed by active compound developer Mibelle Biochemistry.

Swissline’s formula includes RejuveNad at a clinically tested two per cent level, which works by activating NAMPT – the key enzyme that converts nicotinamide into nicotinamide mononucleotide (NMN) – to boost the skin’s own NAD+ production.

This launch marks Swissline’s first step into epigenetic skincare, harnessing the NAD+ pathway to help repair DNA and support skin longevity. Alongside RejuveNad, the formula includes mimetic growth factors, lipids, cholesterol, NMF (natural moisturising factor ingredients) and marine collagen to deeply nourish and plump.

Using 360° Collagen Night Concentrate results in a revitalised complexion, smoother wrinkles and stronger defences against oxidative stress and photo-ageing – leaving skin renewed and resilient.