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HCM research: Old before their time

Researchers say obesity ‘should be considered as premature ageing’, with some negative effects on the immune system being permanent and not reversible by weight loss

Published in Health Club Management 2020 issue 3
Obesity damages the immune system and changes tissue and body composition / photo: shutterstock.com
Obesity damages the immune system and changes tissue and body composition / photo: shutterstock.com
The mechanisms by which the comorbidities of obesity and ageing develop are very similar. Later weight reduction will not always reverse the process

Obesity should be classed as a form of premature ageing, due to it predisposing people to acquiring life-altering diseases normally seen in older individuals.

Authors of a study called Obesity and ageing: Two sides of the same coin – by the Concordia University in Canada, reviewed more than 200 papers relating to obesity’s effects on human health.

Using the data from the papers, they looked at the ways obesity ages the body from a number of different perspectives – from the immune system to shifts in tissue and body composition.

The study was led by Sylvia Santosa, associate professor of health, kinesiology and applied physiology in the Concordia University’s Faculty of Arts and Science.

Santosa and her colleagues looked at the processes of cell death and the maintenance of healthy cells – apoptosis and autophagy, respectively – that are usually associated with ageing.

At the genetic level, the researchers found that obesity influences a number of alterations associated with ageing. These include the shortening of telomeres – the protective caps found on the ends of chromosomes.

The effect of obesity
Telomeres in patients with obesity can be more than 25 per cent shorter than those seen in control patients.

The study also suggests that obesity’s effects on cognitive decline, mobility, hypertension and stress are all similar to those of ageing.

“The mechanisms by which the comorbidities of obesity and ageing develop are very similar,” Santosa said.

Researchers concluded that obesity speeds up the ageing of the immune system by targeting different immune cells, and that later weight reduction will not always reverse the process. The effects of obesity on the immune system, in turn, affect susceptibility to diseases like influenza, which can affect patients with obesity at a higher rate than normal-weight individuals.

Obese people are also at higher risk of sarcopenia, a disease associated with ageing, which features a progressive decline in muscle mass and strength.

Individuals with obesity are also more susceptible to diseases associated with later-life onset, such as type 2 diabetes, Alzheimer’s and various forms of cancer.

Santosa urges health authorities to rethink their approach to obesity, saying: “I’m hoping these observations will focus our approach to understanding obesity better, and allow us to think of it in different ways,” she added.

“We’re asking different types of questions than those which have traditionally been asked,” she concluded.

Obesity and ageing: two sides of the same coin was published in the Obesity Review

http://www.leisureopportunities.com/images/2020/75373_49733.jpg
Researchers say obesity should be considered as a form of premature ageing
Concordia University, Sylvia Santosa,Research, Obesity,
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features

HCM research: Old before their time

Researchers say obesity ‘should be considered as premature ageing’, with some negative effects on the immune system being permanent and not reversible by weight loss

Published in Health Club Management 2020 issue 3
Obesity damages the immune system and changes tissue and body composition / photo: shutterstock.com
Obesity damages the immune system and changes tissue and body composition / photo: shutterstock.com
The mechanisms by which the comorbidities of obesity and ageing develop are very similar. Later weight reduction will not always reverse the process

Obesity should be classed as a form of premature ageing, due to it predisposing people to acquiring life-altering diseases normally seen in older individuals.

Authors of a study called Obesity and ageing: Two sides of the same coin – by the Concordia University in Canada, reviewed more than 200 papers relating to obesity’s effects on human health.

Using the data from the papers, they looked at the ways obesity ages the body from a number of different perspectives – from the immune system to shifts in tissue and body composition.

The study was led by Sylvia Santosa, associate professor of health, kinesiology and applied physiology in the Concordia University’s Faculty of Arts and Science.

Santosa and her colleagues looked at the processes of cell death and the maintenance of healthy cells – apoptosis and autophagy, respectively – that are usually associated with ageing.

At the genetic level, the researchers found that obesity influences a number of alterations associated with ageing. These include the shortening of telomeres – the protective caps found on the ends of chromosomes.

The effect of obesity
Telomeres in patients with obesity can be more than 25 per cent shorter than those seen in control patients.

The study also suggests that obesity’s effects on cognitive decline, mobility, hypertension and stress are all similar to those of ageing.

“The mechanisms by which the comorbidities of obesity and ageing develop are very similar,” Santosa said.

Researchers concluded that obesity speeds up the ageing of the immune system by targeting different immune cells, and that later weight reduction will not always reverse the process. The effects of obesity on the immune system, in turn, affect susceptibility to diseases like influenza, which can affect patients with obesity at a higher rate than normal-weight individuals.

Obese people are also at higher risk of sarcopenia, a disease associated with ageing, which features a progressive decline in muscle mass and strength.

Individuals with obesity are also more susceptible to diseases associated with later-life onset, such as type 2 diabetes, Alzheimer’s and various forms of cancer.

Santosa urges health authorities to rethink their approach to obesity, saying: “I’m hoping these observations will focus our approach to understanding obesity better, and allow us to think of it in different ways,” she added.

“We’re asking different types of questions than those which have traditionally been asked,” she concluded.

Obesity and ageing: two sides of the same coin was published in the Obesity Review

http://www.leisureopportunities.com/images/2020/75373_49733.jpg
Researchers say obesity should be considered as a form of premature ageing
Concordia University, Sylvia Santosa,Research, Obesity,
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Featured supplier: ZIVA & Physical Company: A new partnership to meet all needs
Physical Company and ZIVA have announced a new distribution partnership that will see Physical Company become the exclusive UK distributor of ZIVA's commercial products.
Featured supplier news
Featured supplier: RLSS UK - First choice for all aquatic rescue, pool management, first aid qualifications and training
The Royal Life Saving Society UK (RLSS UK) is proud to be the industry leader in water-related safety qualifications and training. More than 40,000 pool lifeguards qualify with a RLSS UK National Pool Lifeguard Qualification (NPLQ) every year.
Opinion
promotion
The modern training gym champions functional fitness in a small group personal training model, with a premium service experience at its heart
Opinion: Overcome membership attrition with this surprising new industry trend: the modern training gym
Video Gallery
How to use the MZ-Bodyscan
MyZone
The Best Product for the Best Clubs Read more
More videos:
Company profiles
Company profile: Premier Software Solutions Ltd
Premier Software was founded in 1994 and has proven experience developing business management solutions specifically ...
Company profiles
Company profile: Physical Company Ltd
Physical Company provides specialist fitness solutions. This includes equipment, flooring, gym design, programming and training ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Fitness equipment
Healthcheck Services Ltd: Fitness equipment
Fitness software
Go Do.Fitness: Fitness software
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Management software
Fisikal: Management software
Spa software
SpaBooker: Spa software
Exercise equipment
Matrix Fitness: Exercise equipment
Trade associations
International SPA Association - iSPA: Trade associations
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
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Wearable technology solutions
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Greywell, Hampshire
Barnsgrove Health and Wellness Club
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Derby City Council
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Diary dates
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tbc, Beijing, China
Diary dates
04 Jun 2020
Marriott Forest of Arden Hotel & Country Club, Birmingham, United Kingdom
Diary dates
13 Jun 2020
Worldwide, Various,
Diary dates
17-18 Jun 2020
ExCeL London, London, United Kingdom
Diary dates
06-07 Jul 2020
Eastwood Hall, Nottingham, United Kingdom
Diary dates
21-24 Sep 2020
Loews Coronado Bay Resort, Coronado, United States
Diary dates
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Pinggu, Beijing, China
Diary dates
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NEC, Birmingham, United Kingdom
Diary dates
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