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Two forms of nNOS protein required for peak muscle performance
By Luke Tuchscherer
Peak muscle performance needs two separate forms of the nNOS protein, according to a new study.
Research at the University of Washington in Seattle, US, has shown that the nNOS-beta protein is crucial for skeletal muscles in mice and not just the nNOS-mu protein.
The scientists said in the Journal of Clinical Investigation that nNOS-beta is a “critical regulator of the structural and functional integrity of skeletal muscle”.
In essence, during exercise, nNOS-mu signaling maintains blood delivery to active muscle, while nNOS-beta regulates muscle fatigue resistance and post-exercise force output.
Muscles lacking both nNOS-mu and nNOS-beta exhibited profound muscle fatigue and post-exercise weakness.
Peak muscle performance needs two separate forms of the nNOS protein, according to a new study.
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