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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

News

Study: exercise stalls cancer growth by changing T cells in the immune system

Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.

Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the Department of Cell and Molecular Biology, Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells – and thereby improving their ability to attack cancer cells.

Johnson is the author of a study – published in the journal eLife – which makes the connection.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health as well as help us design and improve treatments against cancer,” Johnson said.

To examine how exercise influenced cancer growth, the researchers observed two groups of mice – one which exercised regularly and a group which remained inactive.

In order to understand how exercise influenced cancer growth, the researchers isolated T cells, blood and tissue samples after training sessions and measured levels of common metabolites that are produced in muscle and excreted into plasma at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells isolated from an exercised animal showed an altered metabolism compared to T cells from resting animals.

During the study, it became clear that cancer growth slowed and mortality decreased in the trained animals, when compared with the untrained.

Helene Rundqvist, the study’s first author and senior researcher at the Department of Laboratory Medicine, Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results may contribute to a deeper understanding of how our lifestyle impacts our immune system and inform the development of new immunotherapies against cancer.”

• To download and read the entire study, click here for the eLife journal.

Sign up here to get HCM's weekly ezine and every issue of HCM magazine free on digital.
Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.
HAF,FIT,IND,PTS,RES
2020/THUMB346582_845316_149539.jpg
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Diary dates
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News

Study: exercise stalls cancer growth by changing T cells in the immune system

Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.

Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the Department of Cell and Molecular Biology, Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells – and thereby improving their ability to attack cancer cells.

Johnson is the author of a study – published in the journal eLife – which makes the connection.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health as well as help us design and improve treatments against cancer,” Johnson said.

To examine how exercise influenced cancer growth, the researchers observed two groups of mice – one which exercised regularly and a group which remained inactive.

In order to understand how exercise influenced cancer growth, the researchers isolated T cells, blood and tissue samples after training sessions and measured levels of common metabolites that are produced in muscle and excreted into plasma at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells isolated from an exercised animal showed an altered metabolism compared to T cells from resting animals.

During the study, it became clear that cancer growth slowed and mortality decreased in the trained animals, when compared with the untrained.

Helene Rundqvist, the study’s first author and senior researcher at the Department of Laboratory Medicine, Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results may contribute to a deeper understanding of how our lifestyle impacts our immune system and inform the development of new immunotherapies against cancer.”

• To download and read the entire study, click here for the eLife journal.

Sign up here to get HCM's weekly ezine and every issue of HCM magazine free on digital.
Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.
HAF,FIT,IND,PTS,RES
2020/THUMB346582_845316_149539.jpg

News

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Fuel the debate about issues and opportunities across the industry. We’d love to hear from you – [email protected]
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Featured supplier news
Featured supplier news: Red Light Rising teams up with ITRM Clinic to supply red light therapy for injured athletes
Red light therapy equipment supplier, Red Light Rising, has partnered with Aidan Robinson of ITRM Clinic in the UK
Featured supplier news
Featured supplier news: Cryotherapy specialists, L&R Kältetechnik, launch new artofcryo.com division
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Company profiles
Company profile: Freemotion Fitness
Freemotion Fitness is the global pioneer in fitness equipment and technology, introducing the world to ...
Company profiles
Company profile: FIBO Global Fitness
FIBO Global Fitness is the leading international trade show for fitness, wellness & health....
Catalogue Gallery
Click on a catalogue to view it online
Directory
Wearable technology solutions
MyZone: Wearable technology solutions
Skincare
Sothys: Skincare
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Red Light Therapy
 Red Light Rising: Red Light Therapy
Exercise equipment
Matrix Fitness: Exercise equipment
Lockers/interior design
Fitlockers: Lockers/interior design
Spa software
SpaBooker: Spa software
Management software
Premier Software Solutions: Management software
Fitness equipment
Octane Fitness: Fitness equipment
Architects/designers
Zynk Design Consultants: Architects/designers
Property & Tenders
Hillingdon
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Property & Tenders
Diary dates
12 Jun 2021
Worldwide, Various,
Diary dates
13-14 Jun 2021
Online,
Diary dates
16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
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Expo Centre & Riviera di Rimini, Italy
Diary dates
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Locations worldwide,
Diary dates
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Diary dates
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