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fibodo Limited
fibodo Limited
fibodo Limited
Health Club Management

Health Club Management

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UNITING THE WORLD OF FITNESS
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Health Club Management

Health Club Management

News

Study: exercise stalls cancer growth by changing T cells in the immune system

Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.

Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the Department of Cell and Molecular Biology, Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells – and thereby improving their ability to attack cancer cells.

Johnson is the author of a study – published in the journal eLife – which makes the connection.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health as well as help us design and improve treatments against cancer,” Johnson said.

To examine how exercise influenced cancer growth, the researchers observed two groups of mice – one which exercised regularly and a group which remained inactive.

In order to understand how exercise influenced cancer growth, the researchers isolated T cells, blood and tissue samples after training sessions and measured levels of common metabolites that are produced in muscle and excreted into plasma at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells isolated from an exercised animal showed an altered metabolism compared to T cells from resting animals.

During the study, it became clear that cancer growth slowed and mortality decreased in the trained animals, when compared with the untrained.

Helene Rundqvist, the study’s first author and senior researcher at the Department of Laboratory Medicine, Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results may contribute to a deeper understanding of how our lifestyle impacts our immune system and inform the development of new immunotherapies against cancer.”

• To download and read the entire study, click here for the eLife journal.

Sign up here to get HCM's weekly ezine and every issue of HCM magazine free on digital.
Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.
HAF,FIT,IND,PTS,RES
2020/THUMB346582_845316_149539.jpg
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News

Study: exercise stalls cancer growth by changing T cells in the immune system

Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.

Now, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the Department of Cell and Molecular Biology, Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells – and thereby improving their ability to attack cancer cells.

Johnson is the author of a study – published in the journal eLife – which makes the connection.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health as well as help us design and improve treatments against cancer,” Johnson said.

To examine how exercise influenced cancer growth, the researchers observed two groups of mice – one which exercised regularly and a group which remained inactive.

In order to understand how exercise influenced cancer growth, the researchers isolated T cells, blood and tissue samples after training sessions and measured levels of common metabolites that are produced in muscle and excreted into plasma at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells isolated from an exercised animal showed an altered metabolism compared to T cells from resting animals.

During the study, it became clear that cancer growth slowed and mortality decreased in the trained animals, when compared with the untrained.

Helene Rundqvist, the study’s first author and senior researcher at the Department of Laboratory Medicine, Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results may contribute to a deeper understanding of how our lifestyle impacts our immune system and inform the development of new immunotherapies against cancer.”

• To download and read the entire study, click here for the eLife journal.

Sign up here to get HCM's weekly ezine and every issue of HCM magazine free on digital.
Cancer sufferers who exercise regularly have, generally, a better prognosis than inactive patients – but science hasn't quite managed to agree why this is.
HAF,FIT,IND,PTS,RES
2020/THUMB346582_845316_149539.jpg

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Deansgate Square, the newest residential star on Manchester’s impressive skyline, is a fitting home for some of the city’s most stylish health and fitness facilities, with specialist acoustic flooring by TVS Group
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Catalogue Gallery
Click on a catalogue to view it online
Directory
Lockers/interior design
Safe Space Lockers Ltd: Lockers/interior design
Management software
fibodo Limited: Management software
Uniforms
Service Sport: Uniforms
Spa software
SpaBooker: Spa software
Member feedback software
AskNicely: Member feedback software
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Independent service & maintenance
Servicesport UK Limited: Independent service & maintenance
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fibodo Limited
fibodo Limited