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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

features

Research: Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes

Published in Health Club Management 2020 issue 10
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer

Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

https://www.leisureopportunities.co.uk/images/2020/208955_938109.jpg
A study from the Karolinska Institutet in Sweden suggests exercising can lead to better outcomes in people with cancer
HCM magazine
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Diary dates
23-26 Feb 2021
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03-04 Mar 2021
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Worldwide, Various,
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Online,
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16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
18-19 Sep 2021
Locations worldwide,
Diary dates
21-24 Sep 2021
Messe Stuttgart, Germany
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates

features

Research: Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes

Published in Health Club Management 2020 issue 10
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer

Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

https://www.leisureopportunities.co.uk/images/2020/208955_938109.jpg
A study from the Karolinska Institutet in Sweden suggests exercising can lead to better outcomes in people with cancer
Latest News
What are the effects on public health of gyms and leisure centres being shut during ...
Latest News
Mobile data and analytics provider App Annie has released its State Of Mobile 2021 report, ...
Latest News
The world's largest fitness trade fair, FIBO, has been rescheduled to November. The event will ...
Latest News
PM, Boris Johnson, has confirmed that gyms, swimming pools and leisure centres in England will ...
Latest News
The re-opening of gyms in Wales has been pushed back by the country's First Minister ...
Latest News
The physical and mental health of women in the UK has been put under unprecedented ...
Latest News
Excess body fat and obesity are likely to have contributed to more deaths in England ...
Latest News
The financial performance of health club operator SATS in the last quarter of 2020 was ...
Latest News
FIBO has announced that its Chinese event next month will be held as a hybrid ...
Latest News
Placing gyms and leisure centres at the front of the queue for reopening would be ...
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Data published today (17 February) shows that for every 100,000 visits to UK gyms and ...
Featured supplier news
Featured supplier: AskNicely helps empower businesses to improve customer experience and boost NPS
Maintaining a consistent member experience across a growing health and fitness brand can prove challenging.
Featured supplier news
Featured supplier: What does a socially distanced leisure centre and health club look like?
The world has had to get used to social distancing in 2020 and any business operating in the leisure and hospitality sectors has had to face this challenge more than most.
Company profiles
Company profile: Venueserve Fitness
Venueserve Fitness is an easy-to-use, low-cost web- and mobile online exercise platform, already being used ...
Company profiles
Company profile: Safe Space Lockers
Safe Space have over 25 years of experience in the UK leisure and fitness industry, ...
Supplier Showcases
Supplier showcase - Fisikal
Supplier Showcases
Supplier showcase - Egym: Game changer
Catalogue Gallery
Click on a catalogue to view it online
Directory
Trade associations
International SPA Association - iSPA: Trade associations
Wearable technology solutions
MyZone: Wearable technology solutions
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Exercise equipment
Matrix Fitness: Exercise equipment
Independent service & maintenance
Servicesport UK Limited: Independent service & maintenance
Spa software
SpaBooker: Spa software
Flooring
REGUPOL/Berleburger Schaumstoffwerk (BSW): Flooring
Red Light Therapy
 Red Light Rising: Red Light Therapy
Uniforms
Service Sport: Uniforms
Whole body cryotherapy
Art of Cryo: Whole body cryotherapy
Property & Tenders
Diary dates
23-26 Feb 2021
IFEMA, Madrid, Spain
Diary dates
03-04 Mar 2021
NEC, Birmingham, United Kingdom
Diary dates
03-06 Jun 2021
Expo Centre & Riviera di Rimini, Italy
Diary dates
12 Jun 2021
Worldwide, Various,
Diary dates
13-14 Jun 2021
Online,
Diary dates
16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
18-19 Sep 2021
Locations worldwide,
Diary dates
21-24 Sep 2021
Messe Stuttgart, Germany
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates
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