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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

News

Could exercise be used to treat breast cancer?

Exercise can slow the growth of breast cancer tumours in mice, according to research published in the Journal of the National Cancer Institute.

One way that cancers grow resistant to treatment is by generating a jumbled web of blood vessels which stop oxygen getting to the tumour. When starved of oxygen, the tumour is protected from chemotherapy drugs and radiation, as these treatments are designed to seek out well-oxygenated tissue.

Researchers have tried many different approaches to improve blood flow to tumours, but exercise has proved to be the most promising by far.

“We could not have guessed it would be as effective as it was,” says co-senior author, Mark W Dewhirst. “I have spent the better part of the last 30 years trying to figure out how to eliminate hypoxia in tumours and have looked at a lot of different approaches: drugs, hyperthermia and metabolic manipulations. None has worked very well, and in some cases, made things worse. So these findings with exercise are quite encouraging.”

The researchers used two different models of breast cancer cells and implanted them in mice and then assigned the animals to exercise (running on a wheel), or remaining sedentary.

Tumour growth was significantly slower in animals that exercised than sedentary mice and tumour cell death was 1.5 times higher.

Researchers also tested if exercise would improve the efficacy of the chemotherapy drug, cyclophosphamide. Animals were randomised into four groups: sedentary, exercise alone, cyclophosphamide alone and exercise and cyclophosphamide.

The rate of tumour growth was significantly lower in mice treated with exercise and cyclophosphamide, compared to other groups.

Also significant, tumour growth was delayed in both the exercise alone and cyclophosphamide alone groups, with no difference in the tumour growth rate suggesting that, in this study, exercise was as effective as chemotherapy.

On the basis of these findings, studies are being designed to test whether exercise can inhibit tumour growth and the risk of recurrence in humans.

Exercise can slow the growth of breast cancer tumours in mice, according to research published in the Journal of the National Cancer Institute.
HAF
796920_781373.jpg
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News

Could exercise be used to treat breast cancer?

Exercise can slow the growth of breast cancer tumours in mice, according to research published in the Journal of the National Cancer Institute.

One way that cancers grow resistant to treatment is by generating a jumbled web of blood vessels which stop oxygen getting to the tumour. When starved of oxygen, the tumour is protected from chemotherapy drugs and radiation, as these treatments are designed to seek out well-oxygenated tissue.

Researchers have tried many different approaches to improve blood flow to tumours, but exercise has proved to be the most promising by far.

“We could not have guessed it would be as effective as it was,” says co-senior author, Mark W Dewhirst. “I have spent the better part of the last 30 years trying to figure out how to eliminate hypoxia in tumours and have looked at a lot of different approaches: drugs, hyperthermia and metabolic manipulations. None has worked very well, and in some cases, made things worse. So these findings with exercise are quite encouraging.”

The researchers used two different models of breast cancer cells and implanted them in mice and then assigned the animals to exercise (running on a wheel), or remaining sedentary.

Tumour growth was significantly slower in animals that exercised than sedentary mice and tumour cell death was 1.5 times higher.

Researchers also tested if exercise would improve the efficacy of the chemotherapy drug, cyclophosphamide. Animals were randomised into four groups: sedentary, exercise alone, cyclophosphamide alone and exercise and cyclophosphamide.

The rate of tumour growth was significantly lower in mice treated with exercise and cyclophosphamide, compared to other groups.

Also significant, tumour growth was delayed in both the exercise alone and cyclophosphamide alone groups, with no difference in the tumour growth rate suggesting that, in this study, exercise was as effective as chemotherapy.

On the basis of these findings, studies are being designed to test whether exercise can inhibit tumour growth and the risk of recurrence in humans.

Exercise can slow the growth of breast cancer tumours in mice, according to research published in the Journal of the National Cancer Institute.
HAF
796920_781373.jpg

News

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1 - 20 of 11,793
HCM Magazine
People identify with the challenge. They often see themselves in the fears, barriers and pitfalls; in the family arguments, the late-night doubts – the bits we don’t see in most of the media success stories
HCM Magazine
Sponsored
Welcome to the world of creative fitness, where exercise and fun merge to change the way we train
HCM Magazine
Supplier showcase
Venueserve Fitness is working with the Health Club Collection to drive its digital customer engagement
HCM Magazine
Sponsored
Offering red light therapy to your members can create a valuable source of secondary spend, while also supporting them with their recovery and delivering improvements to mobility, circulation and muscle soreness, as Karen Maxwell explains
HCM Magazine
Interview
COVID survival strategies, growth plans, and a belief that government is finally recognising the value of the fitness sector. The Gym Group CEO speaks to Kate Cracknell
HCM Magazine
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Fitler Club is Philadelphia’s newest private lifestyle club, boasting premium health and wellness facilities, along with a hotel, workspaces and refined culinary venues. Steph Eaves talks to the club’s founder about his creation
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Coming from a personal training background, my experience has taught me that people hire the trainer before the training
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HCM magazine
Stephen Tharrett, co-founder, ClubIntel
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Tracking consumers’ sentiment in relation to lockdowns gives valuable insights into members’ priorities. Leisure-net surveyed the first two UK lockdowns and is currently working on the third. Dave Monkhouse reports on results from the lockdown 2 survey
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Featured supplier news
Featured supplier: Core Health & Fitness announces partnership with Énergie Fitness Iberia
Core Health & Fitness is proud to have signed an exclusive supplier agreement for the roll- out of all projected clubs with Énergie Fitness Iberia over the next seven years.
Featured supplier news
Featured supplier: Precor launches member-focused Preva Mobile app
Precor has launched a mobile app to accompany its popular networked fitness solution, Preva, which has so far recorded almost a billion workouts in more than 11,000 facilities worldwide.
Company profiles
Company profile: Legend Club Management Systems (UK) Ltd
Legend provides the leading software solution for driving improvements in leisure operations. We deliver savings ...
Company profiles
Company profile: FunXtion International BV
Unlock your club’s digital potential with the FunXtion Platform. Deliver engaging and immersive digital fitness ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Member feedback software
AskNicely: Member feedback software
Exercise equipment
Matrix Fitness: Exercise equipment
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Fitness equipment
Precor: Fitness equipment
Flooring
REGUPOL/Berleburger Schaumstoffwerk (BSW): Flooring
Trade associations
International SPA Association - iSPA: Trade associations
Management software
fibodo Limited: Management software
Wearable technology solutions
MyZone: Wearable technology solutions
Independent service & maintenance
Servicesport UK Limited: Independent service & maintenance
Spa software
SpaBooker: Spa software
Property & Tenders
Diary dates
23-26 Feb 2021
IFEMA, Madrid, Spain
Diary dates
03-04 Mar 2021
NEC, Birmingham, United Kingdom
Diary dates
03-06 Jun 2021
Expo Centre & Riviera di Rimini, Italy
Diary dates
12 Jun 2021
Worldwide, Various,
Diary dates
13-14 Jun 2021
Online,
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16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
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Locations worldwide,
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21-24 Sep 2021
Messe Stuttgart, Germany
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