GET HCM
magazine
Sign up for the FREE digital edition of HCM magazine and also get the HCM ezine and breaking news email alerts.
Not right now, thanksclose this window
HID Global
HID Global
HID Global
Follow Health Club Management on Twitter Like Health Club Management on Facebook Join the discussion with Health Club Management on LinkedIn Follow Health Club Management on Instagram
UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

News

Study: physical activity prompts a 'clean-up' of muscles

Physical activity is found to prompt a clean-up of muscles by increasing the activity of protein Ubiquitin, which tags onto worn-out proteins and causes them to degrade.

It is universally accepted that maintaining muscular function is essential and a big part of the human body's ability to do so depends on proteins – the building blocks of muscles.

The proteins do, however, degrade when worn-out and are eventually eliminated in a clean-up process that allows them to be replaced by freshly synthesised proteins.

While extensive knowledge has been accumulated about how muscles regulate the build-up of new proteins during physical training, much less is known about how muscle contractions and exercise serve to clean-up the worn-out proteins.

Now, researchers at the University of Copenhagen’s Department of Nutrition, Exercise and Sports, have demonstrated that a single, intense, 10-minute bicycle ride results in a significant increase in the activity of Ubiquitin, the 'death marker protein' and a subsequent intensification of the targeting and removal of worn-out proteins in muscles.

Ubiquitin itself is a small protein and attaches itself to the amino acid Lysine on worn-out proteins, after which the protein is transported to a Proteasome, which is a structure that, according to the research, "gobbles up proteins and spits them out as amino acids".

These amino acids can then be reused in the synthesis of new proteins. As such, Ubiquitin contributes to a very sustainable circulation of the body's proteins.

Professor Jørgen Wojtaszewski, one of the researchers, says the findings serve to strengthen the entire foundation for the effect of physical activity.

"Basically, it explains part of the reason why physical activity is healthy," he said.

"The beauty is that muscle use, in and of itself, is what initiates the processes that keep muscles 'up to date', healthy and functional."

Professor Bente Kiens, another member of the team, added: "The important role of Ubiquitin for 'cleaning-up' worn-out proteins in connection with muscular activity was not fully appreciated. Now we know that physical activity increases Ubiquitin tagging on these proteins."

For the study, a group of men, aged between 26 and 28 years-old, completed 8-11 minute training sessions an exercise bikes.

Blood tests and muscle biopsies were taken prior to and upon the completion of their training session.

The muscle biopsies were studied using mass spectrometry, which demonstrated how Ubiquitin was used on a large scale to clean up damaged proteins.

• The study, titled Quantification of exercise-regulated ubiquitin signaling in human skeletal muscle identifies protein modification cross talk via NEDDylation in the FASEB Journal. To access the article, click here.

Sign up here to get HCM's weekly ezine and every issue of HCM magazine free on digital.
Physical activity is found to prompt a clean-up of muscles by increasing the activity of protein Ubiquitin, which tags onto worn-out proteins and causes them to degrade.
HAF,FIT,IND,PTS,ACD,RES,PUB
2020/THUMB345633_570730_838882.jpg
Latest News
EuropeActive has joined the All Policies for a Healthy Europe (APHE) initiative, as part of ...
Latest News
Lack of exercise is a major cause of death from COVID-19, according to new research, ...
Latest News
World Leisure Organization (WLO) has opened the entry process for its International Innovation Prize. Now ...
Latest News
Health clubs, leisure centres and studios in England have opened today (12 April) for the ...
Latest News
A major new initiative will look to strengthen and unite the fitness industry's voice in ...
Latest News
A parliamentary report is calling for a £3bn intervention fund to build back better health ...
Latest News
Leisure centre operator Everyone Active has formed a partnership with WW (formerly called Weight Watchers), ...
Latest News
Adults suffering from chronic pain should be advised to take exercise, rather than be prescribed ...
HCM Magazine
Sponsored
Denbighshire Leisure is creating a range of new and unforgettable member experiences. MD, Jamie Groves, explains how a partnership with Technogym and Alliance Leisure has led to the creation of a raft of new offerings
HCM Magazine
Wellness
The team manager of Mahindra Racing talks to Kate Cracknell about creating a new corporate culture in a competitive world – one that places employee wellbeing first
HCM Magazine
Research
Children with better cardiorespiratory health than their peers also do better on cognitive tests and other measures of brain function, according to new research
HCM Magazine
Facilities
Changing rooms have been largely closed during the pandemic, but as clubs open up, how will ongoing pandemic restrictions impact changing room design? We ask the experts for their observations and reflections
HCM Magazine
Interview
As gyms reopen in the UK a new brand is launching that plans to take the boutique market by storm
HCM Magazine
Sponsored
The University of Stirling has transformed its fitness offering with world-class performance sport and fitness facilities powered by Technogym
HCM Magazine
Ask an expert
In spite of having met all government-agreed, COVID-secure operating standards, group exercise has had a rough ride during the pandemic, being closed more than gyms. HCM asks why this is and what can be done about it
HCM Magazine
HCM magazine
New tax laws will hit the UK fitness sector in early April, changing the way freelance PTs are legally classified for income tax and national insurance, as Abi Harris reports
HCM magazine
Policing the rules, even if it means losing members, will be crucial to building trust as health clubs reopen, Paul Roberts tells Kath Hudson
HCM magazine
Fuel the debate about issues and opportunities across the industry. We’d love to hear from you – [email protected]
Featured supplier news
Featured supplier: The Retention People unveil 2020 Member Experience Awards winners
Member engagement software provider The Retention People (TRP) has unveiled the winners of its annual 2020 Member Experience Awards (MEA).
Featured supplier news
Featured supplier: How Gympass reinvented wellbeing
Over the last year, fitness and wellness organisations have faced challenges like never before. When gyms closed and members needed alternative support to keep up their health and wellbeing routines, Gympass swiftly pivoted its business model to offer a wealth of digital solutions for its partners.
Company profiles
Company profile: Octane Fitness
A global innovator of high-performance fitness equipment, Octane Fitness, a Nautilus, Inc. brand, continually redefines ...
Company profiles
Company profile: Parkwood Leisure
Parkwood Leisure is a family-owned leisure management company working with local authority partners across England ...
Supplier Showcases
Supplier showcase - Venueserve Fitness
Catalogue Gallery
Click on a catalogue to view it online
Directory
Fitness equipment
Precor: Fitness equipment
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Whole body cryotherapy
Art of Cryo: Whole body cryotherapy
Lockers/interior design
Safe Space Lockers Ltd: Lockers/interior design
Architects/designers
Zynk Design Consultants: Architects/designers
Spa software
SpaBooker: Spa software
Red Light Therapy
 Red Light Rising: Red Light Therapy
Skincare
Sothys: Skincare
Uniforms
Service Sport: Uniforms
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Property & Tenders
Hillingdon
Hillingdon Borough Council
Property & Tenders
Diary dates
12 Jun 2021
Worldwide, Various,
Diary dates
13-14 Jun 2021
Online,
Diary dates
16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
01-04 Jul 2021
Expo Centre & Riviera di Rimini, Italy
Diary dates
18-19 Sep 2021
Locations worldwide,
Diary dates
21-24 Sep 2021
Messe Stuttgart, Germany
Diary dates
04-07 Nov 2021
Exhibition Centre , Cologne, Germany
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates

News

Study: physical activity prompts a 'clean-up' of muscles

Physical activity is found to prompt a clean-up of muscles by increasing the activity of protein Ubiquitin, which tags onto worn-out proteins and causes them to degrade.

It is universally accepted that maintaining muscular function is essential and a big part of the human body's ability to do so depends on proteins – the building blocks of muscles.

The proteins do, however, degrade when worn-out and are eventually eliminated in a clean-up process that allows them to be replaced by freshly synthesised proteins.

While extensive knowledge has been accumulated about how muscles regulate the build-up of new proteins during physical training, much less is known about how muscle contractions and exercise serve to clean-up the worn-out proteins.

Now, researchers at the University of Copenhagen’s Department of Nutrition, Exercise and Sports, have demonstrated that a single, intense, 10-minute bicycle ride results in a significant increase in the activity of Ubiquitin, the 'death marker protein' and a subsequent intensification of the targeting and removal of worn-out proteins in muscles.

Ubiquitin itself is a small protein and attaches itself to the amino acid Lysine on worn-out proteins, after which the protein is transported to a Proteasome, which is a structure that, according to the research, "gobbles up proteins and spits them out as amino acids".

These amino acids can then be reused in the synthesis of new proteins. As such, Ubiquitin contributes to a very sustainable circulation of the body's proteins.

Professor Jørgen Wojtaszewski, one of the researchers, says the findings serve to strengthen the entire foundation for the effect of physical activity.

"Basically, it explains part of the reason why physical activity is healthy," he said.

"The beauty is that muscle use, in and of itself, is what initiates the processes that keep muscles 'up to date', healthy and functional."

Professor Bente Kiens, another member of the team, added: "The important role of Ubiquitin for 'cleaning-up' worn-out proteins in connection with muscular activity was not fully appreciated. Now we know that physical activity increases Ubiquitin tagging on these proteins."

For the study, a group of men, aged between 26 and 28 years-old, completed 8-11 minute training sessions an exercise bikes.

Blood tests and muscle biopsies were taken prior to and upon the completion of their training session.

The muscle biopsies were studied using mass spectrometry, which demonstrated how Ubiquitin was used on a large scale to clean up damaged proteins.

• The study, titled Quantification of exercise-regulated ubiquitin signaling in human skeletal muscle identifies protein modification cross talk via NEDDylation in the FASEB Journal. To access the article, click here.

Sign up here to get HCM's weekly ezine and every issue of HCM magazine free on digital.
Physical activity is found to prompt a clean-up of muscles by increasing the activity of protein Ubiquitin, which tags onto worn-out proteins and causes them to degrade.
HAF,FIT,IND,PTS,ACD,RES,PUB
2020/THUMB345633_570730_838882.jpg

News

EuropeActive has joined the All Policies for a Healthy Europe (APHE) initiative, as part of
Lack of exercise is a major cause of death from COVID-19, according to new research,
World Leisure Organization (WLO) has opened the entry process for its International Innovation Prize. Now
Health clubs, leisure centres and studios in England have opened today (12 April) for the
A major new initiative will look to strengthen and unite the fitness industry's voice in
A parliamentary report is calling for a £3bn intervention fund to build back better health
fibodo Limited
fibodo Limited
L&R Kältetechnik has launched a new division, named artofcryo.com, after 30 years’ experience with -110
Leisure centre operator Everyone Active has formed a partnership with WW (formerly called Weight Watchers),
Adults suffering from chronic pain should be advised to take exercise, rather than be prescribed
As health clubs and fitness studios in England are counting the hours down to reopening
Empowered Brands, the franchise investment business that acquired énergie Fitness out of a CVA in
John Treharne, founder of The Gym Group, and Jana Havrdová, president of the Czech Chamber
Questex, owner of industry buyer event, Sibec EU, has announced it will partner with FIBO
Global Wellness Summit
Global Wellness Summit
Core Health & Fitness is proud to have signed an exclusive supplier agreement for the
Les Mills has come up with an ingenious solution to get around the pandemic travel
At-home fitness giant Peloton has officially completed the acquisition of equipment provider Precor, in a
There is growing evidence that a COVID-19 infection could trigger diabetes in some patients. One
Danish health club operator Repeat, launched in 2016 by serial fitness entrepreneur Rasmus Ingerslev, has
The UK government has launched a new Office for Health Promotion, designed to lead efforts
Rainer Schaller's RSG Group has opened a John Reed Fitness club in downtown Los Angeles
Safe Space Lockers
Safe Space Lockers
Red light therapy equipment supplier, Red Light Rising has partnered with Aidan Robinson of ITRM
Boutique fitness behemoth Xponential Fitness has added boxing studio operator Rumble to its ever-growing portfolio
A new "supergroup" of boutique fitness brands will look to help pool resources and use
FreeMotion Fitness
FreeMotion Fitness
1 - 20 of 11,849
HCM Magazine
Sponsored
Denbighshire Leisure is creating a range of new and unforgettable member experiences. MD, Jamie Groves, explains how a partnership with Technogym and Alliance Leisure has led to the creation of a raft of new offerings
HCM Magazine
Wellness
The team manager of Mahindra Racing talks to Kate Cracknell about creating a new corporate culture in a competitive world – one that places employee wellbeing first
HCM Magazine
Research
Children with better cardiorespiratory health than their peers also do better on cognitive tests and other measures of brain function, according to new research
HCM Magazine
Facilities
Changing rooms have been largely closed during the pandemic, but as clubs open up, how will ongoing pandemic restrictions impact changing room design? We ask the experts for their observations and reflections
HCM Magazine
Interview
As gyms reopen in the UK a new brand is launching that plans to take the boutique market by storm
HCM Magazine
Sponsored
The University of Stirling has transformed its fitness offering with world-class performance sport and fitness facilities powered by Technogym
HCM Magazine
Ask an expert
In spite of having met all government-agreed, COVID-secure operating standards, group exercise has had a rough ride during the pandemic, being closed more than gyms. HCM asks why this is and what can be done about it
HCM Magazine
HCM magazine
New tax laws will hit the UK fitness sector in early April, changing the way freelance PTs are legally classified for income tax and national insurance, as Abi Harris reports
HCM magazine
Policing the rules, even if it means losing members, will be crucial to building trust as health clubs reopen, Paul Roberts tells Kath Hudson
HCM magazine
Fuel the debate about issues and opportunities across the industry. We’d love to hear from you – [email protected]
HCM magazine
HCM People

Colin Grant

CEO, Pure Group
Meticulous tracing and reporting of cases show, time and time again, that fitness centres and yoga studios are some of the safest places on the planet
HCM magazine
A new tracking tool, called Moving Communities, will assess the impact of the UK’s £100m National Leisure Recovery Fund, as well as evaluating the contribution public sector facilities make to their local communities, as HCM reports
HCM magazine
Hussle’s new Membership Conversion Service proactively turns Hussle customers into direct club members, encouraging them to join clubs they attend regularly
HCM magazine
One of the best aspects of Studio Three is our loyal membership community. Our team has really come to know our members and where they are in their wellness journey
HCM magazine
How will digital, gyms and live fitness mesh to create a new customer offering in health clubs? Phillip Mills, executive director of Les Mills, shares his views
HCM magazine
Katie Lewis and Lindsey Simpson co-founded Workplace Mental Wealth to drive workforce change in the health and fitness industry. Liz Terry talks to Lewis about their first research study – the Fitness and Active Leisure Workforce State of Mind Survey – and the launch of The Good Work Pledge
HCM magazine
Featured supplier news
Featured supplier: The Retention People unveil 2020 Member Experience Awards winners
Member engagement software provider The Retention People (TRP) has unveiled the winners of its annual 2020 Member Experience Awards (MEA).
Featured supplier news
Featured supplier: How Gympass reinvented wellbeing
Over the last year, fitness and wellness organisations have faced challenges like never before. When gyms closed and members needed alternative support to keep up their health and wellbeing routines, Gympass swiftly pivoted its business model to offer a wealth of digital solutions for its partners.
Company profiles
Company profile: Octane Fitness
A global innovator of high-performance fitness equipment, Octane Fitness, a Nautilus, Inc. brand, continually redefines ...
Company profiles
Company profile: Parkwood Leisure
Parkwood Leisure is a family-owned leisure management company working with local authority partners across England ...
Supplier Showcases
Supplier showcase - Venueserve Fitness
Catalogue Gallery
Click on a catalogue to view it online
Directory
Fitness equipment
Precor: Fitness equipment
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Whole body cryotherapy
Art of Cryo: Whole body cryotherapy
Lockers/interior design
Safe Space Lockers Ltd: Lockers/interior design
Architects/designers
Zynk Design Consultants: Architects/designers
Spa software
SpaBooker: Spa software
Red Light Therapy
 Red Light Rising: Red Light Therapy
Skincare
Sothys: Skincare
Uniforms
Service Sport: Uniforms
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Property & Tenders
Hillingdon
Hillingdon Borough Council
Property & Tenders
Diary dates
12 Jun 2021
Worldwide, Various,
Diary dates
13-14 Jun 2021
Online,
Diary dates
16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
01-04 Jul 2021
Expo Centre & Riviera di Rimini, Italy
Diary dates
18-19 Sep 2021
Locations worldwide,
Diary dates
21-24 Sep 2021
Messe Stuttgart, Germany
Diary dates
04-07 Nov 2021
Exhibition Centre , Cologne, Germany
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates
Search news, features & products:
Find a supplier:
HID Global
HID Global