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Les Mills
Health Club Management

Health Club Management

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Health Club Management

Health Club Management

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New drugs dramatically increase healthy lifespan: research

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.

The new research, published by the journal Aging Cell, uses the term “senolytics” for the new class of drug, which was tested on mice but is a step in the right direction toward developing treatments that can be given to humans to extend 'health-span' or to treat age-related diseases and disorders.

The researchers, from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions, believe the drugs may make it possible – in the future – to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time.

Cells that have stopped dividing, ‘senescent’ cells, accumulate with age and accelerate the ageing process. The ‘health-span’ – time free of disease – in mice was enhanced by killing off these cells during the study.

The scientists were then faced with the question of how to identify and target senescent cells without damaging other cells. They found that, like cancer cells, senescent cells have increased expression of ‘pro-survival networks’ that help them resist programmed cell death.

Researchers found two compounds to selectively induce the death of senescent cells: the cancer drug dasatinib and quercetin – a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.

“In animal models [mice] , the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, in addition to an extended health-span,” said researcher Laura Niedernhofer. “Remarkably, in some cases, these drugs did so with only a single course of treatment.”

In old mice, cardiovascular function was improved within five days of a single dose of the drugs. A single dose of a combination of the two drugs led to improved exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months following treatment. Periodic drug administration on mice with accelerated ageing extended their health-span, delaying age-related symptoms, spine degeneration and osteoporosis.

While both drugs have possible side effects and more testing is needed before use in humans, the scientists are positive, however – noting that treatment with senolytic drugs to clear damaged cells would be infrequent, which would reduce the chance of side effects.

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A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.
HAF,SAB,CPW,ACD,RES
796920_781373.jpg
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Rachael Blumberg

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People know yoga, Pilates, HIIT and Barry’s Bootcamp, but many don’t know vibration training and it’s my intention, passion and purpose to make it available and bring it to the world
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News

New drugs dramatically increase healthy lifespan: research

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.

The new research, published by the journal Aging Cell, uses the term “senolytics” for the new class of drug, which was tested on mice but is a step in the right direction toward developing treatments that can be given to humans to extend 'health-span' or to treat age-related diseases and disorders.

The researchers, from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions, believe the drugs may make it possible – in the future – to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time.

Cells that have stopped dividing, ‘senescent’ cells, accumulate with age and accelerate the ageing process. The ‘health-span’ – time free of disease – in mice was enhanced by killing off these cells during the study.

The scientists were then faced with the question of how to identify and target senescent cells without damaging other cells. They found that, like cancer cells, senescent cells have increased expression of ‘pro-survival networks’ that help them resist programmed cell death.

Researchers found two compounds to selectively induce the death of senescent cells: the cancer drug dasatinib and quercetin – a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.

“In animal models [mice] , the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, in addition to an extended health-span,” said researcher Laura Niedernhofer. “Remarkably, in some cases, these drugs did so with only a single course of treatment.”

In old mice, cardiovascular function was improved within five days of a single dose of the drugs. A single dose of a combination of the two drugs led to improved exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months following treatment. Periodic drug administration on mice with accelerated ageing extended their health-span, delaying age-related symptoms, spine degeneration and osteoporosis.

While both drugs have possible side effects and more testing is needed before use in humans, the scientists are positive, however – noting that treatment with senolytic drugs to clear damaged cells would be infrequent, which would reduce the chance of side effects.

Sign up for FREE ezines & magazines
A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.
HAF,SAB,CPW,ACD,RES
796920_781373.jpg

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Mid-market health club operator Total Fitness has acquired Pro-Fit Personal Training. The deal follows a
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As ukactive pushes for government to focus on physical activity for healthcare, Brad Tucker, managing director at Premier Global NASM, explains how the training provider is evolving its programmes to help fitness professionals deliver person-centred, holistic health solutions
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Group exercise
Does your fitness studio offer the antidote to tech-driven loneliness?
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Circuits are a powerful way to deliver a controlled and effective workout to people of a range of abilities in a short time frame. HCM reviews some of the leading systems
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Pulse Fitness has installed a premium fitness facility at The University of Liverpool, fitting the space with its state-of-the-art equipment to appeal to staff and students alike
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you can never sit back and say ‘yeah, we’ve got it now, it’s all sorted’. With each change of government, each change of minister, you have to keep working on those relationships
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people are together on the climbing walls, cheering each other on, coaching each other, interacting, laughing and enjoying each other’s company. It’s a completely different environment from anything I’ve ever seen
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Featured supplier news
Featured supplier: Harlands Effect: Make Your Business More Profitable
Harlands Group is a membership management service for health and fitness operators, which interacts directly with members to effectively manage membership payments.
Featured supplier news
Featured supplier: Gympass expands in Ireland with flagship operator Gym Plus
Gympass, a leader in corporate fitness sales, has expanded its network to Ireland following a new partnership with Gym Plus.
Video Gallery
Harlands Group testimonial
Harlands Group
Harlands Group - Testimonial from 'Unity Leisure'. Read more
More videos:
Company profiles
Company profile: Proinsight Research Ltd
We take time at the outset to understand your unique customer journey. Then we work ...
Company profiles
Company profile: Jordan Fitness
Jordan Fitness have been at the forefront of premium gym design, with a strong reputation ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Spa software
ResortSuite: Spa software
Wearable technology solutions
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Fitness equipment
Dyaco International: Fitness equipment
Audio visual
Hutchison Technologies: Audio visual
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Lockers/interior design
Crown Sports Lockers: Lockers/interior design
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
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Diary dates
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Diary dates
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Diary dates
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Les Mills
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