GET HCM
magazine
Sign up for the FREE digital edition of HCM magazine and also get the HCM ezine and breaking news email alerts.
Not right now, thanksclose this window
FreeMotion Fitness
FreeMotion Fitness
FreeMotion Fitness
Follow Health Club Management on Twitter Like Health Club Management on Facebook Join the discussion with Health Club Management on LinkedIn Follow Health Club Management on Instagram
UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

News

New drugs dramatically increase healthy lifespan: research

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.

The new research, published by the journal Aging Cell, uses the term “senolytics” for the new class of drug, which was tested on mice but is a step in the right direction toward developing treatments that can be given to humans to extend 'health-span' or to treat age-related diseases and disorders.

The researchers, from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions, believe the drugs may make it possible – in the future – to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time.

Cells that have stopped dividing, ‘senescent’ cells, accumulate with age and accelerate the ageing process. The ‘health-span’ – time free of disease – in mice was enhanced by killing off these cells during the study.

The scientists were then faced with the question of how to identify and target senescent cells without damaging other cells. They found that, like cancer cells, senescent cells have increased expression of ‘pro-survival networks’ that help them resist programmed cell death.

Researchers found two compounds to selectively induce the death of senescent cells: the cancer drug dasatinib and quercetin – a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.

“In animal models [mice] , the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, in addition to an extended health-span,” said researcher Laura Niedernhofer. “Remarkably, in some cases, these drugs did so with only a single course of treatment.”

In old mice, cardiovascular function was improved within five days of a single dose of the drugs. A single dose of a combination of the two drugs led to improved exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months following treatment. Periodic drug administration on mice with accelerated ageing extended their health-span, delaying age-related symptoms, spine degeneration and osteoporosis.

While both drugs have possible side effects and more testing is needed before use in humans, the scientists are positive, however – noting that treatment with senolytic drugs to clear damaged cells would be infrequent, which would reduce the chance of side effects.

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.
HAF,SAB,CPW,ACD,RES
796920_781373.jpg
Latest News
Xponential Fitness has acquired Body Fit Training in a deal worth US$44m. The deal takes ...
Latest News
Exercise has been highlighted as a crucial weapon in cancer patients’ battle against the disease. ...
Latest News
The global health and fitness industry is returning to a busy programme of live trade ...
Latest News
Matrix and Intelivideo have signed a strategic partnership, which will see Intelivideo's fitness content integrated ...
Latest News
Nadine Dorries, the recently appointed secretary of state for digital, culture, media and sport at ...
Latest News
Mindbody has announced it's buying ClassPass, the consumer wellness subscription service that enables people to ...
Latest News
Tanni Grey-Thompson has outlined her vision on how the physical activity sector can play "the ...
Latest News
The Global Health & Fitness Alliance (GHFA) has revealed the makeup of its inaugural nine-member ...
HCM Magazine
Sponsored
Billed as the ‘2021 Experience Tour’, Egym has taken its connected gym floor experience on the road around the UK
HCM Magazine
Supplier launch
Life Fitness introduces Integrity SL, the next-generation LED console with intuitive functionality and digital connectivity
HCM Magazine
Editor's letter
The appetite for health clubs is strong among consumers and investors – to take advantage of this, operators must figure out how to meet key challenges in operationally sustainable ways
HCM Magazine
Sponsored
Les Mills is launching a new digital network called Les Mills Connect to help clubs build back better and emerge from the pandemic with a stronger business
HCM Magazine
Sponsored
Andy Janes and Jamie Whisken explain the vision behind R1SE Bournemouth, and why Technogym was their choice of partner in delivering their unique fusion boutique
HCM Magazine
Sponsored
Active IQ is launching courses to upskill fitness professionals to work in social prescribing, extending the reach of the industry
HCM Magazine
Policy
Generations rarely have the opportunity to reset public opinion and effect behaviour change for good, but post-pandemic two unequal movements with a lot in common will be the focus of governments, says David Minton
HCM Magazine
HCM magazine
HCM People

Danielle Obe

Chair, The Black Swimming Association
Our vision is a future with ethnic diversity in aquatics
HCM magazine
David Minton says the healthy movement industry is ten times bigger than the health club sector, and the care industry four times bigger and ask why we’re not rushing to collaborate?
HCM magazine
Screens display power generated from each piece of equipment, allowing people to compete against each other for kilowatt hours produced
Featured supplier news
Featured supplier news: Are traditional gyms going to war with smart gyms?
CEO of Orbit4, Daniel Jones, says: “There’s no reason traditional gyms and smart gyms can’t live in harmony. With a little reorganisation and education, there’s a really bright future for all gyms.”
Featured supplier news
Featured supplier news: Active IQ Skills Hub helps fitness professionals boost skills in post-Covid market
Suffice to say that the pandemic has completely changed the way fitness professionals work and the way consumers work out – and therein lies opportunity.
Featured operator news
Featured operator news: Everyone Active generates £342m in social value
Award-winning leisure operator Everyone Active generated £342million in social value at its sites across the country in 2019/20.
Featured operator news
Featured operator news: Being active helps Parkwood Leisure customers save the NHS £16m
Parkwood Leisure, one of the UK’s leading public leisure facilities operators, helped prevent more than 7,000 cases of stroke, dementia, depression and type 2 diabetes in 2019, saving the NHS £16 million, a new social value report has shown.
Company profiles
Company profile: Hussle
Hussle exists for two reasons: To increase opportunities for people to engage in physical activity ...
Company profiles
Company profile: Magicline GmbH
For more than 30 years, Magicline has been driving the digitalisation of the fitness industry ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Red Light Therapy
 Red Light Rising: Red Light Therapy
Wearable technology solutions
MyZone: Wearable technology solutions
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Independent service & maintenance
Servicesport UK Limited: Independent service & maintenance
Management software
Premier Software Solutions: Management software
trade associations
International SPA Association - iSPA: trade associations
Exercise equipment
Power Plate: Exercise equipment
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Spa software
SpaBooker: Spa software
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Property & Tenders
Welwyn Garden City
Welwyn Hatfield Borough Council
Property & Tenders
Newport, Shropshire
Lilleshall Sports Academy
Property & Tenders
Diary dates
01-03 Feb 2022
Coventry Building Society Arena, Coventry, United Kingdom
Diary dates
07-10 Apr 2022
Exhibition Centre , Cologne, Germany
Diary dates
15-16 Jun 2022
ExCeL London, London, United Kingdom
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates

News

New drugs dramatically increase healthy lifespan: research

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.

The new research, published by the journal Aging Cell, uses the term “senolytics” for the new class of drug, which was tested on mice but is a step in the right direction toward developing treatments that can be given to humans to extend 'health-span' or to treat age-related diseases and disorders.

The researchers, from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions, believe the drugs may make it possible – in the future – to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time.

Cells that have stopped dividing, ‘senescent’ cells, accumulate with age and accelerate the ageing process. The ‘health-span’ – time free of disease – in mice was enhanced by killing off these cells during the study.

The scientists were then faced with the question of how to identify and target senescent cells without damaging other cells. They found that, like cancer cells, senescent cells have increased expression of ‘pro-survival networks’ that help them resist programmed cell death.

Researchers found two compounds to selectively induce the death of senescent cells: the cancer drug dasatinib and quercetin – a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.

“In animal models [mice] , the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, in addition to an extended health-span,” said researcher Laura Niedernhofer. “Remarkably, in some cases, these drugs did so with only a single course of treatment.”

In old mice, cardiovascular function was improved within five days of a single dose of the drugs. A single dose of a combination of the two drugs led to improved exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months following treatment. Periodic drug administration on mice with accelerated ageing extended their health-span, delaying age-related symptoms, spine degeneration and osteoporosis.

While both drugs have possible side effects and more testing is needed before use in humans, the scientists are positive, however – noting that treatment with senolytic drugs to clear damaged cells would be infrequent, which would reduce the chance of side effects.

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.
HAF,SAB,CPW,ACD,RES
796920_781373.jpg

News

Xponential Fitness has acquired Body Fit Training in a deal worth US$44m. The deal takes
Exercise has been highlighted as a crucial weapon in cancer patients’ battle against the disease.
The global health and fitness industry is returning to a busy programme of live trade
Matrix and Intelivideo have signed a strategic partnership, which will see Intelivideo's fitness content integrated
Nadine Dorries, the recently appointed secretary of state for digital, culture, media and sport at
Mindbody has announced it's buying ClassPass, the consumer wellness subscription service that enables people to
Les Mills
Les Mills
Matt Miller, founder of leading yoga training platform Broga has announced the launch of Earth+Sky
Tanni Grey-Thompson has outlined her vision on how the physical activity sector can play "the
The Global Health & Fitness Alliance (GHFA) has revealed the makeup of its inaugural nine-member
The 40th Annual IHRSA International Convention & Trade Show (IHRSA 2021) begins today in Dallas,
A new study has suggested that strength training can result in people losing around a
Basic-Fit has officially opened its 1,000th club, with the launch of a new site in
Health club operator Life Time Group has become a publicly traded company again, after it
Innovatise UK Ltd
Innovatise UK Ltd
The best in class of the physical activity sector have been revealed at the ukactive
Creating workout experiences will be the main theme of this year's Retention Convention, which will
Marg Mayne will stand down as CEO of Mytime Active next year, after more than
French car manufacturer Citroën and hotel brand Pullman Hotels & Resorts have partnered to create
Les Mills is expanding its digital operations by replacing its existing on-demand services with the
Sport England has spent £1.5m launching its own on-demand fitness platform, with the hope of
New research by Barclays Corporate Banking reveals that the leisure, fitness, spa and hospitality industries
FreeMotion Fitness
FreeMotion Fitness
“At least 40 per cent of all businesses will die in the next 10 years
Tanni Grey-Thompson has announced she will hand over her role as ukactive chair in August
A group of leading health and fitness companies in Romania have joined forces to launch
Miha Bodytec GmbH
Miha Bodytec GmbH
1 - 20 of 12,048
HCM Magazine
Sponsored
Billed as the ‘2021 Experience Tour’, Egym has taken its connected gym floor experience on the road around the UK
HCM Magazine
Supplier launch
Life Fitness introduces Integrity SL, the next-generation LED console with intuitive functionality and digital connectivity
HCM Magazine
Editor's letter
The appetite for health clubs is strong among consumers and investors – to take advantage of this, operators must figure out how to meet key challenges in operationally sustainable ways
HCM Magazine
Sponsored
Les Mills is launching a new digital network called Les Mills Connect to help clubs build back better and emerge from the pandemic with a stronger business
HCM Magazine
Sponsored
Andy Janes and Jamie Whisken explain the vision behind R1SE Bournemouth, and why Technogym was their choice of partner in delivering their unique fusion boutique
HCM Magazine
Sponsored
Active IQ is launching courses to upskill fitness professionals to work in social prescribing, extending the reach of the industry
HCM Magazine
Policy
Generations rarely have the opportunity to reset public opinion and effect behaviour change for good, but post-pandemic two unequal movements with a lot in common will be the focus of governments, says David Minton
HCM Magazine
HCM magazine
HCM People

Danielle Obe

Chair, The Black Swimming Association
Our vision is a future with ethnic diversity in aquatics
HCM magazine
David Minton says the healthy movement industry is ten times bigger than the health club sector, and the care industry four times bigger and ask why we’re not rushing to collaborate?
HCM magazine
Screens display power generated from each piece of equipment, allowing people to compete against each other for kilowatt hours produced
HCM magazine
Our equipment doesn't consume power but does generate it, recycling human energy
HCM magazine
Our competition need to fasten their seatbelts
HCM magazine
In this issue, we’re focusing on sharing insights and thought leadership to highlight opportunities for the development of the sector in terms of both markets and offerings
HCM magazine
Booming membership sales, busy suburban clubs and members visiting during the working day. Operators are reporting it’s good to be back. Kath Hudson finds out what business has been like since the re-set button was pressed
HCM magazine
GLL is best known for running leisure facilities on behalf of local authorities across the UK, but a lesser-known part of its remit is its GLL Sport Foundation which supports Olympic hopefuls. Liz Terry finds out more
HCM magazine
Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen
HCM magazine
Featured supplier news
Featured supplier news: Are traditional gyms going to war with smart gyms?
CEO of Orbit4, Daniel Jones, says: “There’s no reason traditional gyms and smart gyms can’t live in harmony. With a little reorganisation and education, there’s a really bright future for all gyms.”
Featured supplier news
Featured supplier news: Active IQ Skills Hub helps fitness professionals boost skills in post-Covid market
Suffice to say that the pandemic has completely changed the way fitness professionals work and the way consumers work out – and therein lies opportunity.
Featured operator news
Featured operator news: Everyone Active generates £342m in social value
Award-winning leisure operator Everyone Active generated £342million in social value at its sites across the country in 2019/20.
Featured operator news
Featured operator news: Being active helps Parkwood Leisure customers save the NHS £16m
Parkwood Leisure, one of the UK’s leading public leisure facilities operators, helped prevent more than 7,000 cases of stroke, dementia, depression and type 2 diabetes in 2019, saving the NHS £16 million, a new social value report has shown.
Company profiles
Company profile: Hussle
Hussle exists for two reasons: To increase opportunities for people to engage in physical activity ...
Company profiles
Company profile: Magicline GmbH
For more than 30 years, Magicline has been driving the digitalisation of the fitness industry ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Red Light Therapy
 Red Light Rising: Red Light Therapy
Wearable technology solutions
MyZone: Wearable technology solutions
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Independent service & maintenance
Servicesport UK Limited: Independent service & maintenance
Management software
Premier Software Solutions: Management software
trade associations
International SPA Association - iSPA: trade associations
Exercise equipment
Power Plate: Exercise equipment
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Spa software
SpaBooker: Spa software
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Property & Tenders
Welwyn Garden City
Welwyn Hatfield Borough Council
Property & Tenders
Newport, Shropshire
Lilleshall Sports Academy
Property & Tenders
Diary dates
01-03 Feb 2022
Coventry Building Society Arena, Coventry, United Kingdom
Diary dates
07-10 Apr 2022
Exhibition Centre , Cologne, Germany
Diary dates
15-16 Jun 2022
ExCeL London, London, United Kingdom
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates
Search news, features & products:
Find a supplier:
FreeMotion Fitness
FreeMotion Fitness