Zimmer MedizinSysteme GmbH / icelab
Zimmer MedizinSysteme GmbH / icelab
Zimmer MedizinSysteme GmbH / icelab
Health Club Management

Health Club Management

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UNITING THE WORLD OF FITNESS
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Health Club Management

Health Club Management

News

New drugs dramatically increase healthy lifespan: research

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.

The new research, published by the journal Aging Cell, uses the term “senolytics” for the new class of drug, which was tested on mice but is a step in the right direction toward developing treatments that can be given to humans to extend 'health-span' or to treat age-related diseases and disorders.

The researchers, from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions, believe the drugs may make it possible – in the future – to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time.

Cells that have stopped dividing, ‘senescent’ cells, accumulate with age and accelerate the ageing process. The ‘health-span’ – time free of disease – in mice was enhanced by killing off these cells during the study.

The scientists were then faced with the question of how to identify and target senescent cells without damaging other cells. They found that, like cancer cells, senescent cells have increased expression of ‘pro-survival networks’ that help them resist programmed cell death.

Researchers found two compounds to selectively induce the death of senescent cells: the cancer drug dasatinib and quercetin – a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.

“In animal models [mice] , the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, in addition to an extended health-span,” said researcher Laura Niedernhofer. “Remarkably, in some cases, these drugs did so with only a single course of treatment.”

In old mice, cardiovascular function was improved within five days of a single dose of the drugs. A single dose of a combination of the two drugs led to improved exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months following treatment. Periodic drug administration on mice with accelerated ageing extended their health-span, delaying age-related symptoms, spine degeneration and osteoporosis.

While both drugs have possible side effects and more testing is needed before use in humans, the scientists are positive, however – noting that treatment with senolytic drugs to clear damaged cells would be infrequent, which would reduce the chance of side effects.

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A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.
HAF,SAB,CPW,ACD,RES
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Abbeycroft Leisure - Inspiring better health and wellbeing for Suffolk communities
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In 20 years’ time, by helping our population to become fitter and healthier, projects like this can reduce our workload
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We have 14 rockstar instructors, all freelance but all working for us on an exclusive basis, and haven’t lost a single one of them since we opened. We pay them well – they can earn €100+ for a full class. But even more important than that, they all feel involved in the business
People
In addition to being one of the UK’s largest leisure management companies, Parkwood Leisure is also a health and fitness operator at scale, with 73 gyms and over 100,000 members. MD Glen Hall tells HCM how two major reviews in recent years have put the company on a new path
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News

New drugs dramatically increase healthy lifespan: research

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.

The new research, published by the journal Aging Cell, uses the term “senolytics” for the new class of drug, which was tested on mice but is a step in the right direction toward developing treatments that can be given to humans to extend 'health-span' or to treat age-related diseases and disorders.

The researchers, from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions, believe the drugs may make it possible – in the future – to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time.

Cells that have stopped dividing, ‘senescent’ cells, accumulate with age and accelerate the ageing process. The ‘health-span’ – time free of disease – in mice was enhanced by killing off these cells during the study.

The scientists were then faced with the question of how to identify and target senescent cells without damaging other cells. They found that, like cancer cells, senescent cells have increased expression of ‘pro-survival networks’ that help them resist programmed cell death.

Researchers found two compounds to selectively induce the death of senescent cells: the cancer drug dasatinib and quercetin – a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.

“In animal models [mice] , the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, in addition to an extended health-span,” said researcher Laura Niedernhofer. “Remarkably, in some cases, these drugs did so with only a single course of treatment.”

In old mice, cardiovascular function was improved within five days of a single dose of the drugs. A single dose of a combination of the two drugs led to improved exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months following treatment. Periodic drug administration on mice with accelerated ageing extended their health-span, delaying age-related symptoms, spine degeneration and osteoporosis.

While both drugs have possible side effects and more testing is needed before use in humans, the scientists are positive, however – noting that treatment with senolytic drugs to clear damaged cells would be infrequent, which would reduce the chance of side effects.

Sign up for FREE ezines & magazines
A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.
HAF,SAB,CPW,ACD,RES
796920_781373.jpg

News

Food labelling that shows the amount of exercise needed to burn off the calories in
The team at unusually named studio //3877 has created a boxing gym in Washington, D.C.,
Boutique fitness operator Barry's is entering the indoor cycling market with Barry's Ride – a
Getting fit together could be the secret for a long happy relationship. A new study
Not-for profit leisure operator Circadian Trust is partnering with NHS GP surgeries in Gloucestershire to
ukactive has launched two major new reports as part of its Business Intelligence service. The
EMD UK
EMD UK
Drummond Health & Fitness Education Academy has been providing quality health and fitness training and
The annual Sweat event kicks off in London today (20 February), offering the UK's fitness
Boutique boxing gym brand BXR London has revealed plans to open its second site at
Rising workplace stress among employees has led companies to increase their investment in incentives as
David Lloyd Leisure is facing prosecution by Leeds Council over alleged health and safety breaches,
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A self-help studio marketing itself as a "first-of-its-kind self-development wellness space" will open in the
Alliance Leisure
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Focus Training
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1 - 15 of 11,269
Features
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Features
HCM research
You could help members reduce feelings of sadness, conquer binge-eating and improve self-control, using learnings from the Journal of Consumer Psychology, reports Megan Whitby
Features
feature
HCM talks to Fraser Smith about founding his studio and why he picked miha bodytec as his supplier and EMS training for his USP
Features
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Class Boutique Fitness has collaborated with Physical Company to create a boutique studio offering that’s as inclusive as it is effective
Features
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New research from Mintel reveals private health and fitness clubs had a record breaking year in 2019. Mintel’s Lauren Ryan gives us the highlights
Features
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Third Space sold its boutique brand, Another Space, and launched its sixth full-service club in the space of a few weeks, signalling its intention to consoldidate its position at the top end of the market
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feature
Abbeycroft Leisure - Inspiring better health and wellbeing for Suffolk communities
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In 20 years’ time, by helping our population to become fitter and healthier, projects like this can reduce our workload
People
We have 14 rockstar instructors, all freelance but all working for us on an exclusive basis, and haven’t lost a single one of them since we opened. We pay them well – they can earn €100+ for a full class. But even more important than that, they all feel involved in the business
People
In addition to being one of the UK’s largest leisure management companies, Parkwood Leisure is also a health and fitness operator at scale, with 73 gyms and over 100,000 members. MD Glen Hall tells HCM how two major reviews in recent years have put the company on a new path
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HCM people

Stephen Aucott & Matt Brown

Odyssey Health Club and Spa
We’d like to think we’re offering something unique that will encourage members to grow their own vegetables and reconnect to their relationship with food
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HCM people

Duncan Jefford

Regional Director, Everyone Active
People don’t want to just come in and run on a treadmill or sit on a bike, they want an experience
People
HCM people

Amanda Daley

Professor of behavioural medicine, Loughborough University
PACE labelling would be a simple, user-friendly way of informing people, at a glance, of the amount of physical activity required for the food they are considering eating
People
People have been coming back to me for more than 35 years – I take them to another dimension as they progress, because the dimensions are endless
People
HCM people

Kam Panesar

Awakn: Founder and CEO
Years of studying the greats – Michael Jordan, Kobe Bryant, Albert Einstein, Steve Jobs – combined with my own life lessons – led to the Awakn 7 pillars process and my goal to Awakn London
People
We have a new flagship location in Bangkok called Icon Siam – which is spread over three floors, with an infinity pool and the country’s first dedicated Lagree Pilates studio. We’ve also opened The F Zone in Bangkok, which is a heart rate training, athletic performance club
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Job search
POST YOUR JOB
Featured supplier news
Featured supplier: WEXO: The definitive cross training solution
A new cross training concept has arrived, offering weightlifting, athletic, metabolic, and functional exercises in a circuit format.
Featured supplier news
Featured supplier: active-net unveils Gen Z-themed agenda
Active-net 2020 has revealed the agenda for the two-day educational, networking and business meetings event, which takes place next month.
Video Gallery
How to use the MZ-Bodyscan
MyZone
The Best Product for the Best Clubs Read more
More videos:
Company profiles
Company profile: Wattbike
Wattbike is the creator of the world’s most advanced and innovative indoor bikes, developed in ...
Company profiles
Company profile: Fisikal Limited
Fisikal helps fitness professionals, operators and education organisations improve efficiencies and service through its online ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Lockers/interior design
Fitlockers: Lockers/interior design
Exercise equipment
Technogym: Exercise equipment
Trade associations
International SPA Association - iSPA: Trade associations
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Wearable technology solutions
MyZone: Wearable technology solutions
Skincare
Comfort Zone - Davines S.p.A: Skincare
Direct debit solutions
Harlands Group: Direct debit solutions
Fitness equipment
Healthcheck Services Ltd: Fitness equipment
Professional services
Deloitte UK: Professional services
Locking solutions
Monster Padlocks: Locking solutions
Property & Tenders
Derby City Council
Property & Tenders
Diary dates
06-07 Mar 2020
Palazzo del Ghiaccio, Milan, Italy
Diary dates
23-25 Mar 2020
Hilton, Barcelona, Spain
Diary dates
25 Mar 2020
Executive Boardroom, Middlesex University, London, United Kingdom
Diary dates
25-26 Mar 2020
Eastwood Hall, Nottingham, United Kingdom
Diary dates
26-29 Mar 2020
The Winter Gardens Blackpool, Blackpool , United Kingdom
Diary dates
27-29 Mar 2020
TeatroGoya Multiespacio, Madrid, Spain
Diary dates
19-24 Apr 2020
tbc, Beijing, China
Diary dates
04 Jun 2020
Marriott Forest of Arden Hotel & Country Club, Birmingham, United Kingdom
Diary dates
13 Jun 2020
Worldwide, Various,
Diary dates
17-18 Jun 2020
ExCeL London, London, United Kingdom
Diary dates
21-24 Sep 2020
Loews Coronado Bay Resort, Coronado, United States
Diary dates
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Pinggu, Beijing, China
Diary dates
30-31 Oct 2020
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Diary dates
27-28 Nov 2020
Athena, Leicester, United Kingdom
Diary dates
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Zimmer MedizinSysteme GmbH / icelab
Zimmer MedizinSysteme GmbH / icelab