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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

News

New drugs dramatically increase healthy lifespan: research

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.

The new research, published by the journal Aging Cell, uses the term “senolytics” for the new class of drug, which was tested on mice but is a step in the right direction toward developing treatments that can be given to humans to extend 'health-span' or to treat age-related diseases and disorders.

The researchers, from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions, believe the drugs may make it possible – in the future – to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time.

Cells that have stopped dividing, ‘senescent’ cells, accumulate with age and accelerate the ageing process. The ‘health-span’ – time free of disease – in mice was enhanced by killing off these cells during the study.

The scientists were then faced with the question of how to identify and target senescent cells without damaging other cells. They found that, like cancer cells, senescent cells have increased expression of ‘pro-survival networks’ that help them resist programmed cell death.

Researchers found two compounds to selectively induce the death of senescent cells: the cancer drug dasatinib and quercetin – a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.

“In animal models [mice] , the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, in addition to an extended health-span,” said researcher Laura Niedernhofer. “Remarkably, in some cases, these drugs did so with only a single course of treatment.”

In old mice, cardiovascular function was improved within five days of a single dose of the drugs. A single dose of a combination of the two drugs led to improved exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months following treatment. Periodic drug administration on mice with accelerated ageing extended their health-span, delaying age-related symptoms, spine degeneration and osteoporosis.

While both drugs have possible side effects and more testing is needed before use in humans, the scientists are positive, however – noting that treatment with senolytic drugs to clear damaged cells would be infrequent, which would reduce the chance of side effects.

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.
HAF,SAB,CPW,ACD,RES
796920_781373.jpg
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"Prescribing exercise will always be preferential to prescribing painkillers, given the risks associated with their long-term use"
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The UK’s first dedicated leisure development framework has completed its first four-year term with £144m committed investment in public leisure projects.
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News

New drugs dramatically increase healthy lifespan: research

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.

The new research, published by the journal Aging Cell, uses the term “senolytics” for the new class of drug, which was tested on mice but is a step in the right direction toward developing treatments that can be given to humans to extend 'health-span' or to treat age-related diseases and disorders.

The researchers, from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions, believe the drugs may make it possible – in the future – to delay, prevent, alleviate or even reverse multiple chronic diseases and disabilities as a group, instead of just one at a time.

Cells that have stopped dividing, ‘senescent’ cells, accumulate with age and accelerate the ageing process. The ‘health-span’ – time free of disease – in mice was enhanced by killing off these cells during the study.

The scientists were then faced with the question of how to identify and target senescent cells without damaging other cells. They found that, like cancer cells, senescent cells have increased expression of ‘pro-survival networks’ that help them resist programmed cell death.

Researchers found two compounds to selectively induce the death of senescent cells: the cancer drug dasatinib and quercetin – a natural compound sold as a supplement that acts as an antihistamine and anti-inflammatory.

“In animal models [mice] , the compounds improved cardiovascular function and exercise endurance, reduced osteoporosis and frailty, in addition to an extended health-span,” said researcher Laura Niedernhofer. “Remarkably, in some cases, these drugs did so with only a single course of treatment.”

In old mice, cardiovascular function was improved within five days of a single dose of the drugs. A single dose of a combination of the two drugs led to improved exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months following treatment. Periodic drug administration on mice with accelerated ageing extended their health-span, delaying age-related symptoms, spine degeneration and osteoporosis.

While both drugs have possible side effects and more testing is needed before use in humans, the scientists are positive, however – noting that treatment with senolytic drugs to clear damaged cells would be infrequent, which would reduce the chance of side effects.

A new class of drugs has been identified that dramatically slows the ageing process, alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan, according to a recent study.
HAF,SAB,CPW,ACD,RES
796920_781373.jpg

News

Indoor group exercise can recommence in England and Scotland today (17 May), as part of
Thousands of health clubs, swimming pools and leisure centres are under the threat of permanent
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A court has given Virgin Active the green light to erase the rent arrears it
Miha Bodytec GmbH
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With gyms and leisure centres in England reopened, and the rest of the UK due
The Swimming Teachers' Association (STA) has partnered with a psychologist to provide new mindfulness and
A report commissioned by Parkrun has estimated that allowing mass-participation outdoor events carries an "exceptionally
Jan Spaticchia, founder and chair of énergie Fitness has died aged 51 following a short
A new pioneering approach looks to help cancer patients prepare for and respond to treatment
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HCM Magazine
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A new report, conducted by Deloitte, analyses the growth of the Chinese fitness industry and the outlook ahead, as Kristen Walsh reports
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"Prescribing exercise will always be preferential to prescribing painkillers, given the risks associated with their long-term use"
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HCM People

Helena Field

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Opinion
promotion
The UK’s first dedicated leisure development framework has completed its first four-year term with £144m committed investment in public leisure projects.
Opinion: UK’s first leisure framework celebrates £144m investment in public leisure
Featured supplier news
Featured supplier news: Cryotherapy specialists, L&R Kältetechnik, launch new artofcryo.com division
L&R Kältetechnik has launched a new division, named artofcryo.com, after 30 years’ experience with -110 °C electrical solutions.
Featured supplier news
Featured supplier news: Marc Jones joins Fitronics in new head of commercial role
Marc Jones has joined Fitronics, the company behind The Retention People (TRP) and CoursePro, in a newly created role of Head of Commercial.
Company profiles
Company profile: IONTO Health & Beauty GmbH
IONTO-COMED offers a wide range of treatment beds offering maximum flexibility and the symbiosis of ...
Company profiles
Company profile: Hussle
Hussle exists for two reasons: To increase opportunities for people to engage in physical activity ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Uniforms
Service Sport: Uniforms
Spa software
SpaBooker: Spa software
Whole body cryotherapy
Art of Cryo: Whole body cryotherapy
Fitness equipment
Octane Fitness: Fitness equipment
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Wearable technology solutions
MyZone: Wearable technology solutions
Trade associations
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Pendine Sands, Carmarthenshire
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Diary dates
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Virtual summit,
Diary dates
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Diary dates
13-14 Jun 2021
Online,
Diary dates
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Expo Centre & Riviera di Rimini, Italy
Diary dates
18-19 Sep 2021
Locations worldwide,
Diary dates
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