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Health Club Management

Health Club Management

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UNITING THE WORLD OF FITNESS
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Health Club Management

Health Club Management

features

Research: Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes

Published in Health Club Management 2020 issue 10
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer

Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

https://www.leisureopportunities.co.uk/images/2020/208955_938109.jpg
A study from the Karolinska Institutet in Sweden suggests exercising can lead to better outcomes in people with cancer
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IFEMA, Madrid, Spain
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features

Research: Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes

Published in Health Club Management 2020 issue 10
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer

Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

https://www.leisureopportunities.co.uk/images/2020/208955_938109.jpg
A study from the Karolinska Institutet in Sweden suggests exercising can lead to better outcomes in people with cancer
Latest News
Nick Whitcombe, the independent gym owner who refused to shut his gym during the October ...
Latest News
This year's UK government Spending Review, announced in Parliament by chancellor Rishi Sunak on 25 ...
Latest News
Up to 100k people will benefit from the free gym and physical activity sessions, thanks ...
Latest News
To the relief of the sector, the UK government confirmed yesterday (23 November) that gyms, ...
Latest News
Closing gyms and leisure facilities during any possible future lockdown would be "unthinkable", according to ...
Latest News
The University of Stirling has opened its new £20m sports and fitness centre. The building, ...
Latest News
Gyms are right near the bottom of the list in terms of places people have ...
Latest News
A new, Europe-wide initiative will look to chart the level of risk of COVID-19 infection ...
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UK Parliament will debate COVID-19 restrictions on gyms and leisure centres on Monday 23 November, ...
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The UK government has launched a £1bn Public Sector Decarbonisation Scheme (PSDS), providing grant funding ...
Opinion
promotion
With January now close on the horizon your thoughts will be firmly focused on sales campaigns to attract new members through your doors in the new year rush.
Opinion: Sealing the Leaky Bucket – 7 Research-Based Tips for Retaining New Members in January 2021
Featured supplier news
Featured supplier: Cryotherapy specialists, L&R Kältetechnik, launch new artofcryo.com division
L&R Kältetechnik has launched a new division, named artofcryo.com, after 30 years’ experience with -110 °C electrical solutions.
Featured supplier news
Featured supplier: Dr Paul Bedford announces Retention Convention will go virtual for 2020
Global retention expert, Dr Paul Bedford, will host his sixth annual Retention Convention virtually, bringing together global speakers to form a documentary-style event around turning customers into communities.
Video Gallery
Freemotion 22 SERIES Powered by iFit
FreeMotion Fitness
The only connected fitness experience in commercial fitness centers, powered by iFit. Read more
More videos:
Company profiles
Company profile: Volution
Volution uses data to connect the digital with the physical and partners with health and ...
Company profiles
Company profile: MoveGB
Move is the fitness marketplace connecting our partners with customers through the largest variety of ...
Supplier Showcases
Supplier showcase - Powering through
Catalogue Gallery
Click on a catalogue to view it online
Directory
Management software
fibodo Limited: Management software
Fitness Software
FunXtion International BV: Fitness Software
Locking solutions
Monster Padlocks: Locking solutions
Independent service & maintenance
Servicesport UK Limited: Independent service & maintenance
Design consultants
Zynk Design Consultants: Design consultants
Skincare
Sothys: Skincare
Spa software
SpaBooker: Spa software
Member feedback software
AskNicely: Member feedback software
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Trade associations
International SPA Association - iSPA: Trade associations
Property & Tenders
11 - 25 Union St, London SE1 1SD
Bankside Open Spaces Trust
Property & Tenders
Waltham Abbey, Essex
Lee Valley Regional Park Authority
Property & Tenders
Diary dates
03-03 Dec 2020
Virtual,
Diary dates
09 Dec 2020
Raffles City Convention Centre, Singapore, Singapore
Diary dates
02-04 Feb 2021
Ericsson Exhibition Hall, Ricoh Arena, Coventry, United Kingdom
Diary dates
23-26 Feb 2021
IFEMA, Madrid, Spain
Diary dates
03-04 Mar 2021
NEC, Birmingham, United Kingdom
Diary dates
03-06 Jun 2021
Expo Centre & Riviera di Rimini, Italy
Diary dates
16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates
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