GET HCM
magazine
Sign up for the FREE digital edition of HCM magazine and also get the HCM ezine and breaking news email alerts.
Not right now, thanksclose this window
Les Mills
Les Mills
Les Mills
Health Club Management

Health Club Management

Follow Health Club Management on Twitter Like Health Club Management on Facebook Join the discussion with Health Club Management on LinkedIn Follow Health Club Management on Instagram
UNITING THE WORLD OF FITNESS
Get the latest news, jobs and features in your inbox
Health Club Management

Health Club Management

features

Research: Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes

Published in Health Club Management 2020 issue 10
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer

Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

https://www.leisureopportunities.co.uk/images/2020/208955_938109.jpg
A study from the Karolinska Institutet in Sweden suggests exercising can lead to better outcomes in people with cancer
HCM magazine
We’ve stepped off the path this month to bring you a special 2020 review edition of HCM and to propose emerging priorities going forward, as we gird our loins to tackle 2021
HCM magazine
High quality user experience and good value for the operator. This is the winning formula behind an expanding Physical Company product range, says James Anderson
HCM magazine
Nu Physio and Fitness has placed Egym at the heart of its protection and prevention model
HCM Magazine
Sponsored
Technogym introduced live and on-demand functionality to Mywellness in July. Here we find out more about operators who have adopted this solution
HCM Magazine
Profile
The chair of énergie and vice chair of BMF talks to Kate Cracknell about creating an omnichannel approach that brings together indoor, outdoor, online and VR
HCM Magazine
Active ageing
With many older people in crisis due to the pandemic, ukactive’s head of health and wellbeing development, Kenny Butler, explains why the organisation is launching an active ageing consultation and how you can get involved
HCM Magazine
Sponsored
Andy Hall, COO of data and tech solutions brand, Volution, looks at the trends we can expect to see emerging in the global fitness market in 2021
HCM Magazine
Supplier showcase
Bulmershe Leisure Centre, run by Places Leisure, is providing its community with state-of-the-art fitness machines from Octane Fitness
HCM Magazine
Sponsored
Ruskin Fitness Club has transformed its gym in partnership with Technogym, adding the new Excite Live line, as well as dedicated workout zones
HCM Magazine
News report
A new study from the Global Wellness Institute highlights the scope of the $121bn mental wellness market, as Katie Barnes and Megan Whitby report
HCM Magazine
Latest News
One of England's highest ranking police officers has called on government ministers to clearly define ...
Latest News
Virtuagym, a leading provider of fitness technology for gyms and trainers, has announced the launch ...
Latest News
Fitness First has launched a new free digital fitness hub, offering users a wide range ...
Latest News
The Gym Group has brought in Rio Ferdinand and Wais Shaifta as non-executive directors, signalling ...
Latest News
As the global vaccine rollout brings reopening closer and heralds the end of lockdowns, jostling ...
Latest News
Less than half (44.9 per cent) of children and young people in England met the ...
Latest News
An England-wide survey of over 5,000 adults found that 80 per cent of people aged ...
Latest News
The government needs to provide the fitness and physical activity sector with a plan which ...
Featured supplier news
Featured supplier: Cryotherapy specialists, L&R Kältetechnik, launch new artofcryo.com division
L&R Kältetechnik has launched a new division, named artofcryo.com, after 30 years’ experience with -110 °C electrical solutions.
Featured supplier news
Featured supplier: Pulse Fitness updates iGym London with state-of-the-art technology
Pulse Fitness has recently completed a refurbishment of the fitness facilities at iGym London.
Video Gallery
CPASE creates unforgettable luxury member experience at new boutique club with Technogym
Technogym
Technogym has equipped Clare Stobart's new boutique health club – CPASE. Read more
More videos:
Company profiles
Company profile: Life Fitness
Through our Life Fitness Solutions Partners, we can deliver design and build services, finance solutions, ...
Company profiles
Company profile: MiE FitQuest
FitQuest (MiE Medical Research) are specialists in the field of human performance measurement. We have ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Fitness equipment
TRX Training: Fitness equipment
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Red Light Therapy
 Red Light Rising: Red Light Therapy
Wearable technology solutions
MyZone: Wearable technology solutions
Spa software
SpaBooker: Spa software
Software
Volution.fit: Software
Lockers/interior design
Crown Sports Lockers: Lockers/interior design
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Uniforms
Service Sport: Uniforms
Exercise equipment
Technogym: Exercise equipment
Property & Tenders
11 - 25 Union St, London SE1 1SD
Bankside Open Spaces Trust
Property & Tenders
Waltham Abbey, Essex
Lee Valley Regional Park Authority
Property & Tenders
Diary dates
02-04 Feb 2021
Ericsson Exhibition Hall, Ricoh Arena, Coventry, United Kingdom
Diary dates
23-26 Feb 2021
IFEMA, Madrid, Spain
Diary dates
03-04 Mar 2021
NEC, Birmingham, United Kingdom
Diary dates
03-06 Jun 2021
Expo Centre & Riviera di Rimini, Italy
Diary dates
16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
21-24 Sep 2021
Messe Stuttgart, Germany
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates

features

Research: Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes

Published in Health Club Management 2020 issue 10
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer

Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

https://www.leisureopportunities.co.uk/images/2020/208955_938109.jpg
A study from the Karolinska Institutet in Sweden suggests exercising can lead to better outcomes in people with cancer
Latest News
One of England's highest ranking police officers has called on government ministers to clearly define ...
Latest News
Virtuagym, a leading provider of fitness technology for gyms and trainers, has announced the launch ...
Latest News
Fitness First has launched a new free digital fitness hub, offering users a wide range ...
Latest News
The Gym Group has brought in Rio Ferdinand and Wais Shaifta as non-executive directors, signalling ...
Latest News
As the global vaccine rollout brings reopening closer and heralds the end of lockdowns, jostling ...
Latest News
Less than half (44.9 per cent) of children and young people in England met the ...
Latest News
An England-wide survey of over 5,000 adults found that 80 per cent of people aged ...
Latest News
The government needs to provide the fitness and physical activity sector with a plan which ...
Latest News
Book4Time, a leading cloud-based business management solution for the global hospitality, spa and wellness industry, ...
Latest News
Some Brits drop their exercise habits, eat unhealthily and drink more alcohol during lockdowns, according ...
Latest News
New year, new celeb workout as Mark ‘Bez’ Berry announces the launch of his own ...
Featured supplier news
Featured supplier: Cryotherapy specialists, L&R Kältetechnik, launch new artofcryo.com division
L&R Kältetechnik has launched a new division, named artofcryo.com, after 30 years’ experience with -110 °C electrical solutions.
Featured supplier news
Featured supplier: Pulse Fitness updates iGym London with state-of-the-art technology
Pulse Fitness has recently completed a refurbishment of the fitness facilities at iGym London.
Video Gallery
CPASE creates unforgettable luxury member experience at new boutique club with Technogym
Technogym
Technogym has equipped Clare Stobart's new boutique health club – CPASE. Read more
More videos:
Company profiles
Company profile: Life Fitness
Through our Life Fitness Solutions Partners, we can deliver design and build services, finance solutions, ...
Company profiles
Company profile: MiE FitQuest
FitQuest (MiE Medical Research) are specialists in the field of human performance measurement. We have ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Fitness equipment
TRX Training: Fitness equipment
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Red Light Therapy
 Red Light Rising: Red Light Therapy
Wearable technology solutions
MyZone: Wearable technology solutions
Spa software
SpaBooker: Spa software
Software
Volution.fit: Software
Lockers/interior design
Crown Sports Lockers: Lockers/interior design
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Uniforms
Service Sport: Uniforms
Exercise equipment
Technogym: Exercise equipment
Property & Tenders
11 - 25 Union St, London SE1 1SD
Bankside Open Spaces Trust
Property & Tenders
Waltham Abbey, Essex
Lee Valley Regional Park Authority
Property & Tenders
Diary dates
02-04 Feb 2021
Ericsson Exhibition Hall, Ricoh Arena, Coventry, United Kingdom
Diary dates
23-26 Feb 2021
IFEMA, Madrid, Spain
Diary dates
03-04 Mar 2021
NEC, Birmingham, United Kingdom
Diary dates
03-06 Jun 2021
Expo Centre & Riviera di Rimini, Italy
Diary dates
16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
21-24 Sep 2021
Messe Stuttgart, Germany
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates
Search news, features & products:
Find a supplier:
Les Mills
Les Mills