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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

features

Research: HIIT in the spotlight

Researchers have shed new light on the effects of HIIT on skeletal muscle, according to a study published on the eLife platform

Published in Health Club Management 2022 issue 5
The 5-week study involved eight healthy, untrained males / PHOTO: Shutterstock/YAKOBCHUK VIACHESLAV
The 5-week study involved eight healthy, untrained males / PHOTO: Shutterstock/YAKOBCHUK VIACHESLAV
The study showed an increase in the production of proteins used to build mitochondria, which produce energy in cells

The study – carried out using a sample of men – suggests that HIIT workouts boost the amount of proteins in skeletal muscle that are essential for energy metabolism and muscle contraction, while also chemically altering key metabolic proteins.

“Exercising has many beneficial effects that can help prevent and treat metabolic diseases,” says Morten Hostrup, first and co-corresponding author and associate professor at the Department of Nutrition, Exercise, and Sports at the University of Copenhagen. “This is likely to be the result of changes in energy use by skeletal muscles.

“We wanted to understand how exercise alters the muscles’ protein content and how it regulates the activity of these proteins through a chemical reaction called acetylation.”

These results may explain the beneficial effects of HIIT on metabolism, and pave the way for additional studies exploring how exercise impacts these processes.

The study involved eight healthy, untrained male volunteers who completed five weeks of high-intensity cycling training, working out three times per week, finishing four minutes of cycling at a target rate of more than 90 per cent of their maximum heart rate, followed by a two-minute rest. They repeated this pattern four to five times per workout.

Using mass spectrometry, the team analysed changes to the composition of 3,168 proteins in tissue samples collected from the participants’ thighs, before the study and after they completed the training. They also examined changes relating to 1,263 lysine acetyl-sites on 464 acetylated proteins.

Their analyses showed an increase in the production of proteins used to build mitochondria, which produce energy in cells, and in proteins related to muscle contractions, as well as changes in the amount of proteins that reduce the skeletal muscle’s calcium sensitivity, which is essential for muscle contractions.

“This provides new information about how skeletal muscle adapts to exercise, including the identification of novel exercise-regulated proteins and acetyl-sites,” says co-corresponding author Atul Deshmukh, of the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen. “We hope our work will stimulate further research into how exercise helps improve metabolic health in humans.”

https://www.leisureopportunities.co.uk/images/2022/826775_516215.jpg
European researchers have shed new light on the impact of HIIT on skeletal muscle, according to a recent study.
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Researchers have shed new light on the effects of HIIT on skeletal muscle, according to a study published on the eLife platform
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features

Research: HIIT in the spotlight

Researchers have shed new light on the effects of HIIT on skeletal muscle, according to a study published on the eLife platform

Published in Health Club Management 2022 issue 5
The 5-week study involved eight healthy, untrained males / PHOTO: Shutterstock/YAKOBCHUK VIACHESLAV
The 5-week study involved eight healthy, untrained males / PHOTO: Shutterstock/YAKOBCHUK VIACHESLAV
The study showed an increase in the production of proteins used to build mitochondria, which produce energy in cells

The study – carried out using a sample of men – suggests that HIIT workouts boost the amount of proteins in skeletal muscle that are essential for energy metabolism and muscle contraction, while also chemically altering key metabolic proteins.

“Exercising has many beneficial effects that can help prevent and treat metabolic diseases,” says Morten Hostrup, first and co-corresponding author and associate professor at the Department of Nutrition, Exercise, and Sports at the University of Copenhagen. “This is likely to be the result of changes in energy use by skeletal muscles.

“We wanted to understand how exercise alters the muscles’ protein content and how it regulates the activity of these proteins through a chemical reaction called acetylation.”

These results may explain the beneficial effects of HIIT on metabolism, and pave the way for additional studies exploring how exercise impacts these processes.

The study involved eight healthy, untrained male volunteers who completed five weeks of high-intensity cycling training, working out three times per week, finishing four minutes of cycling at a target rate of more than 90 per cent of their maximum heart rate, followed by a two-minute rest. They repeated this pattern four to five times per workout.

Using mass spectrometry, the team analysed changes to the composition of 3,168 proteins in tissue samples collected from the participants’ thighs, before the study and after they completed the training. They also examined changes relating to 1,263 lysine acetyl-sites on 464 acetylated proteins.

Their analyses showed an increase in the production of proteins used to build mitochondria, which produce energy in cells, and in proteins related to muscle contractions, as well as changes in the amount of proteins that reduce the skeletal muscle’s calcium sensitivity, which is essential for muscle contractions.

“This provides new information about how skeletal muscle adapts to exercise, including the identification of novel exercise-regulated proteins and acetyl-sites,” says co-corresponding author Atul Deshmukh, of the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen. “We hope our work will stimulate further research into how exercise helps improve metabolic health in humans.”

https://www.leisureopportunities.co.uk/images/2022/826775_516215.jpg
European researchers have shed new light on the impact of HIIT on skeletal muscle, according to a recent study.
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Featured supplier news: Dr Paul Bedford and Andreas Paulsen to speak at Sibec Europe-UK
Questex’s Sibec Europe-UK, Europe’s leading hosted buyer event for the fitness industry, will take place on 27-30 September 2022 at the Anantara Vilamoura Algarve Resort, in Portugal.
Featured operator news
Featured operator news: New £42m Moorways Sports Village to open on 21 May
Everyone Active will open Moorways Sports Village to the public on Saturday 21 May with a grand opening weekend – in time for the half term holidays.
Featured operator news
Featured operator news: Parkwood Leisure celebrates four award wins and named Outstanding Organisation of the Year at the 2022 ukactive Awards
It was a night to remember at the 2022 ukactive Awards for Parkwood Leisure, as the leisure facilities operator picked up four awards.
Video Gallery
Sport Alliance GmbH
Mindbody, Inc
Total Vibration Solutions / Floors 4 Gyms / TVS Sports Surfaces
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Company profile: Life Fitness
The Life Fitness family of brands offers an unrivalled product portfolio, providing customers with access ...
Company profiles
Company profile: Indigofitness Ltd
We Create Training Spaces! We've been designing and delivering high quality training spaces for almost ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Fitness equipment
A Panatta Sport Srl: Fitness equipment
Architects/designers
Zynk Design Consultants: Architects/designers
Spa software
SpaBooker: Spa software
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