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Les Mills International
Les Mills International
Les Mills International
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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

features

Research: Exercise can counter diabetes damage

Being physically active can heal damage caused by diabetes, enabling the activation of a natural system that grows new blood vessels, according to research in the US

Published in Health Club Management 2022 issue 4
One 45 minute ssession was enough to register a positive impact / Shutterstock/Juice Flair
One 45 minute ssession was enough to register a positive impact / Shutterstock/Juice Flair
Exercise can simulate the growth of new blood vessels when existing ones are ravaged by diabetes

Diabetes not only damages existing blood vessels but also hinders the body’s innate ability to grow new ones in the face of disease and injury.

Scientists at Medical College of Georgia (MCG), however, have found that exercise can help enable angiogenesis – the formation of new blood vessels – which in turn reverses the damage caused by diabetes.

In a study published in The FASEB Journal, a team at MCG’s Vascular Biology Center found the first evidence that in the face of diabetes, even one 45-minute session of moderate-intensity exercise prompts the release of more exosomes into the blood to deliver more of the protein ATP7A directly to cells, which can set angiogenesis in motion. Exosomes are submicroscopic packages filled with biologically active ‘cargo’.

One cardio session
In a sample of healthy 50-something-year-olds, one cardio session increased levels of ATP7A in the exosomes that attached to endothelial cells.

Exercise also increased levels of extracellular superoxide dismutase (SOD3), an important natural antioxidant produced by vascular smooth muscle cells in the walls of blood vessels, as well as skeletal muscle cells, which helps maintain healthy levels of reactive oxygen species or ROS.

ROS is a natural byproduct of our use of oxygen that is an important cell signal, enabling a variety of functions. But in diabetes, high blood sugar levels result in higher ROS levels that instead hinder important normal functions.

Dr Tohru Fukai, MCG vascular biologist and cardiologist and lead author of the study, said: “ATP7A levels are reduced in diabetes and we now have some of the first evidence that exosomes actually impair angiogenesis among those with Type 2 diabetes.

Read the full research report: Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3 at www.hcmmag.com/angiogenic

https://www.leisureopportunities.co.uk/images/2022/535084_535875.jpg
Exercise can stimulate the growth of new blood vessels when existing ones are ravaged by diabetes, find researchers
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features

Research: Exercise can counter diabetes damage

Being physically active can heal damage caused by diabetes, enabling the activation of a natural system that grows new blood vessels, according to research in the US

Published in Health Club Management 2022 issue 4
One 45 minute ssession was enough to register a positive impact / Shutterstock/Juice Flair
One 45 minute ssession was enough to register a positive impact / Shutterstock/Juice Flair
Exercise can simulate the growth of new blood vessels when existing ones are ravaged by diabetes

Diabetes not only damages existing blood vessels but also hinders the body’s innate ability to grow new ones in the face of disease and injury.

Scientists at Medical College of Georgia (MCG), however, have found that exercise can help enable angiogenesis – the formation of new blood vessels – which in turn reverses the damage caused by diabetes.

In a study published in The FASEB Journal, a team at MCG’s Vascular Biology Center found the first evidence that in the face of diabetes, even one 45-minute session of moderate-intensity exercise prompts the release of more exosomes into the blood to deliver more of the protein ATP7A directly to cells, which can set angiogenesis in motion. Exosomes are submicroscopic packages filled with biologically active ‘cargo’.

One cardio session
In a sample of healthy 50-something-year-olds, one cardio session increased levels of ATP7A in the exosomes that attached to endothelial cells.

Exercise also increased levels of extracellular superoxide dismutase (SOD3), an important natural antioxidant produced by vascular smooth muscle cells in the walls of blood vessels, as well as skeletal muscle cells, which helps maintain healthy levels of reactive oxygen species or ROS.

ROS is a natural byproduct of our use of oxygen that is an important cell signal, enabling a variety of functions. But in diabetes, high blood sugar levels result in higher ROS levels that instead hinder important normal functions.

Dr Tohru Fukai, MCG vascular biologist and cardiologist and lead author of the study, said: “ATP7A levels are reduced in diabetes and we now have some of the first evidence that exosomes actually impair angiogenesis among those with Type 2 diabetes.

Read the full research report: Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3 at www.hcmmag.com/angiogenic

https://www.leisureopportunities.co.uk/images/2022/535084_535875.jpg
Exercise can stimulate the growth of new blood vessels when existing ones are ravaged by diabetes, find researchers
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Featured supplier news: EGYM: A digital ecosystem that works for everyone
EGYM has been pioneering the connected gym floor for more than a decade, partnering with operators and other third-party integrations, to create a free-flowing training environment that places the member at the very centre of the experience.
Featured supplier news
Featured supplier news: Good news for the fitness industry, a unique opportunity awaits gyms
In just over two years, the fitness industry has experienced major disruptions to gyms, a boom in at-home fitness and the return of in-person workouts.
Featured operator news
Featured operator news: New £42m Moorways Sports Village to open on 21 May
Everyone Active will open Moorways Sports Village to the public on Saturday 21 May with a grand opening weekend – in time for the half term holidays.
Featured operator news
Featured operator news: Parkwood Leisure celebrates four award wins and named Outstanding Organisation of the Year at the 2022 ukactive Awards
It was a night to remember at the 2022 ukactive Awards for Parkwood Leisure, as the leisure facilities operator picked up four awards.
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Total Vibration Solutions / Floors 4 Gyms / TVS Sports Surfaces
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Company profile: IONTO Health & Beauty GmbH
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Company profile: We Work Well Inc
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Click on a catalogue to view it online
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Featured press releases: Go! Active leisure facility gets a New Year Upgrade
In 2016, Bolsover District Council’s Go! Active leisure facility in Clowne, Derbyshire benefited from a multi-million pound development.
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Diary dates
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