Les Mills
Les Mills
Les Mills
Health Club Management

Health Club Management

Follow Health Club Management on Twitter Like Health Club Management on Facebook Join the discussion with Health Club Management on LinkedIn Follow Health Club Management on Instagram
UNITING THE WORLD OF FITNESS
Get the latest news, jobs and features in your inbox
Health Club Management

Health Club Management

features

Fasting find

A groundbreaking study has found that fasting can help regenerate the immune system and could have a role to play in healthy ageing

By Katie Barnes, Spa Business | Published in Health Club Management 2014 issue 11
Fasting can help the
body regenerate its
immune system / PHOTO: WWW.SHUTTERSTOCK.COM/ALEXANDER PEKOUR
Fasting can help the body regenerate its immune system/ PHOTO: WWW.SHUTTERSTOCK.COM/ALEXANDER PEKOUR

Abstaining from eating for periods of two to four days at a time not only helps to protect the immune system from damage, but also leads to cell regeneration, according to a groundbreaking new piece of research*.

Scientists at the University of Southern California (USC) in the US say this is the first time a natural intervention has been found to trigger stem cell-based self-renewal of an organ or system. And the findings could have major implications for healthy ageing.

As people age, their immune system declines, making them more susceptible to disease; being able to prevent or reverse this process could help prevent illness in this group. It could also potentially benefit those with autoimmune disorders, and cancer patients whose immune systems are weakened by chemotherapy.

Flipping the switch Over a course of six months, the scientists looked at the impact prolonged fasting cycles had on mice as well as patients undergoing chemotherapy. Both the mice and the people went without food for two- to four-day periods.

In both cases, not eating initially lowered the white blood cell counts – the cells that defend the body against disease – as the body started getting rid of old or damaged cells. “When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged,” explains lead study author Valter Longo, a professor of gerontology and biological sciences at USC.

Eventually, however, prolonged periods of fasting in mice then “flipped a regenerative switch” which kick-started the stem cells into producing brand new white blood cells. This essentially rebooted the whole immune system.

The PKA enzyme
Importantly, the scientists also found that, when people don’t eat for long periods, levels of the enzyme PKA are lowered in the body. In previous studies, PKA has been linked to the regulation of stem cell self-renewal and the potential for one cell to develop into many different cell types.

“PKA is the key gene that needs to shut down in order for these stem cells to switch into regenerative mode,” clarifies Longo, who’s also the director of USC’s Longevity Institute.

“It gives the OK for stem cells to go ahead and begin proliferating and rebuild the entire system. And the good news is that the body got rid of the parts of the system that might be damaged or old, the inefficient parts, during the fasting. Now, if you start with a system heavily damaged by chemotherapy or ageing, fasting cycles can generate, literally, a new immune system.”

Additional benefits
Other results from the study, which was published in the Cell Stem Cell journal in June, showed that long periods of fasting lowered levels of IGF-1, a growth hormone that’s associated with ageing, tumour progression and cancer risk.

In another pilot clinical trial on a small group of chemotherapy patients, Longo discovered that fasting for a 72-hour period before treatment protected the body against toxicity.

* Longo, V et al. Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeration and Reverse Immunosuppression, Cell Stem Cell, June 2014

http://www.leisureopportunities.com/images/320792_839502.jpg
A groundbreaking US study has found that fasting can strengthen the immune system, and may have a role to play in healthy ageing
People
One of the opportunities we’re looking at is in London. The location doesn’t suit a low-cost gym, but would suit a boutique-style model. - John Oxley
People
We’re trying to help people understand exactly how much effort they need to apply in order to get the best outcome, so they can do it over a long period of time and not burn out. The overall training effect is then much better
People
HCM people

Rachael Blumberg

Platefit: creator and founder
People know yoga, Pilates, HIIT and Barry’s Bootcamp, but many don’t know vibration training and it’s my intention, passion and purpose to make it available and bring it to the world
Features
feature
“We can include those yet to take the plunge into wearables,” says Myzone’s Dave Wright
Features
feature
As ukactive pushes for government to focus on physical activity for healthcare, Brad Tucker, managing director at Premier Global NASM, explains how the training provider is evolving its programmes to help fitness professionals deliver person-centred, holistic health solutions
Features
Group exercise
Does your fitness studio offer the antidote to tech-driven loneliness?
Features
Circuits
Circuits are a powerful way to deliver a controlled and effective workout to people of a range of abilities in a short time frame. HCM reviews some of the leading systems
Features
Supplier showcase
With the first of a planned 105 clubs across the UK and Ireland up and running, UFC GYM turned to the expertise of DFC to ensure a simpler membership process for members
Features
Supplier showcase
Pulse Fitness has installed a premium fitness facility at The University of Liverpool, fitting the space with its state-of-the-art equipment to appeal to staff and students alike
Features
IHRSA Update
IHRSA’s Kristen Walsh shares highlights from The 2019 IHRSA Health Club Consumer Report into the US fitness market, as well as giving universal advice about how to stay relevant
Features
Latest News
Mid-market health club operator Total Fitness has acquired Pro-Fit Personal Training. The deal follows a ...
Latest News
PureGym is set to become the second largest fitness operator in Europe, after revealing plans ...
Latest News
The Glass House Retreat, a new eco-friendly health and wellness retreat, has opened in Bulphan, ...
Latest News
A large-scale study on genetics has shown that being more physically active reduces the risk ...
Latest News
The Gym Group has confirmed plans to roll out a new small box format in ...
Latest News
Representatives from the three main political parties have backed the view that physical activity has ...
Latest News
Life Leisure is expanding its facility portfolio with the launch of an independent boutique fitness ...
Latest News
Almost half of children and young people (46.8 per cent) in England are doing the ...
Job search
POST YOUR JOB
Featured supplier news
Featured supplier: Who does your brand belong to?
Who does your brand belong to? There used to be only one answer to this question: the company that grew it and invested in it.
Featured supplier news
Featured supplier: Gympass expands in Ireland with flagship operator Gym Plus
Gympass, a leader in corporate fitness sales, has expanded its network to Ireland following a new partnership with Gym Plus.
Company profiles
Company profile: TRX Training UK
TRX provides world-class functional training by offering quality equipment, effective workouts and world-class education capable ...
Company profiles
Company profile: Balanced Body®
Stocked in the UK for fast, costeffective delivery, Balanced Body® delivers versatile and space-saving mind-body ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Wearable technology solutions
MyZone: Wearable technology solutions
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Skincare
Comfort Zone - Davines S.p.A: Skincare
Trade associations
International SPA Association - iSPA: Trade associations
Direct debit solutions
Harlands Group: Direct debit solutions
Management software
GymSales: Management software
Lockers/interior design
Fitlockers: Lockers/interior design
Locking solutions
Ojmar: Locking solutions
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Property & Tenders
Diary dates
21-23 Jan 2020
Harrogate Convention Centre, Harrogate, United Kingdom
Diary dates
28-30 Jan 2020
Ericsson Exhibition Hall, Ricoh Arena, Coventry, United Kingdom
Diary dates
29-30 Jan 2020
Holiday Inn San Francisco-Golden Gateway, San Francisco, United States
Diary dates
23-25 Mar 2020
Hilton, Barcelona, Spain
Diary dates
25-26 Mar 2020
Eastwood Hall, Nottingham, United Kingdom
Diary dates
19-24 Apr 2020
tbc, Beijing, China
Diary dates
04 Jun 2020
Marriott Forest of Arden Hotel & Country Club, Birmingham, United Kingdom
Diary dates
10-27 Jun 2020
tbc, Pinggu, China
Diary dates
13 Jun 2020
Worldwide, Various,
Diary dates
17-18 Jun 2020
ExCeL London, London, United Kingdom
Diary dates
21-24 Sep 2020
Loews Coronado Bay Resort, Coronado, United States
Diary dates
30-31 Oct 2020
NEC, Birmingham, United Kingdom
Diary dates

features

Fasting find

A groundbreaking study has found that fasting can help regenerate the immune system and could have a role to play in healthy ageing

By Katie Barnes, Spa Business | Published in Health Club Management 2014 issue 11
Fasting can help the
body regenerate its
immune system / PHOTO: WWW.SHUTTERSTOCK.COM/ALEXANDER PEKOUR
Fasting can help the body regenerate its immune system/ PHOTO: WWW.SHUTTERSTOCK.COM/ALEXANDER PEKOUR

Abstaining from eating for periods of two to four days at a time not only helps to protect the immune system from damage, but also leads to cell regeneration, according to a groundbreaking new piece of research*.

Scientists at the University of Southern California (USC) in the US say this is the first time a natural intervention has been found to trigger stem cell-based self-renewal of an organ or system. And the findings could have major implications for healthy ageing.

As people age, their immune system declines, making them more susceptible to disease; being able to prevent or reverse this process could help prevent illness in this group. It could also potentially benefit those with autoimmune disorders, and cancer patients whose immune systems are weakened by chemotherapy.

Flipping the switch Over a course of six months, the scientists looked at the impact prolonged fasting cycles had on mice as well as patients undergoing chemotherapy. Both the mice and the people went without food for two- to four-day periods.

In both cases, not eating initially lowered the white blood cell counts – the cells that defend the body against disease – as the body started getting rid of old or damaged cells. “When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged,” explains lead study author Valter Longo, a professor of gerontology and biological sciences at USC.

Eventually, however, prolonged periods of fasting in mice then “flipped a regenerative switch” which kick-started the stem cells into producing brand new white blood cells. This essentially rebooted the whole immune system.

The PKA enzyme
Importantly, the scientists also found that, when people don’t eat for long periods, levels of the enzyme PKA are lowered in the body. In previous studies, PKA has been linked to the regulation of stem cell self-renewal and the potential for one cell to develop into many different cell types.

“PKA is the key gene that needs to shut down in order for these stem cells to switch into regenerative mode,” clarifies Longo, who’s also the director of USC’s Longevity Institute.

“It gives the OK for stem cells to go ahead and begin proliferating and rebuild the entire system. And the good news is that the body got rid of the parts of the system that might be damaged or old, the inefficient parts, during the fasting. Now, if you start with a system heavily damaged by chemotherapy or ageing, fasting cycles can generate, literally, a new immune system.”

Additional benefits
Other results from the study, which was published in the Cell Stem Cell journal in June, showed that long periods of fasting lowered levels of IGF-1, a growth hormone that’s associated with ageing, tumour progression and cancer risk.

In another pilot clinical trial on a small group of chemotherapy patients, Longo discovered that fasting for a 72-hour period before treatment protected the body against toxicity.

* Longo, V et al. Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeration and Reverse Immunosuppression, Cell Stem Cell, June 2014

http://www.leisureopportunities.com/images/320792_839502.jpg
A groundbreaking US study has found that fasting can strengthen the immune system, and may have a role to play in healthy ageing
Latest News
Mid-market health club operator Total Fitness has acquired Pro-Fit Personal Training. The deal follows a ...
Latest News
PureGym is set to become the second largest fitness operator in Europe, after revealing plans ...
Latest News
The Glass House Retreat, a new eco-friendly health and wellness retreat, has opened in Bulphan, ...
Latest News
A large-scale study on genetics has shown that being more physically active reduces the risk ...
Latest News
The Gym Group has confirmed plans to roll out a new small box format in ...
Latest News
Representatives from the three main political parties have backed the view that physical activity has ...
Latest News
Life Leisure is expanding its facility portfolio with the launch of an independent boutique fitness ...
Latest News
Almost half of children and young people (46.8 per cent) in England are doing the ...
Latest News
A local fitness operator with 11 clubs in Chicago, US, is looking to muscle in ...
Latest News
Fitness industry veteran Nick Coutts has been appointed chair of Danish fitness tech firm Motosumo. ...
Latest News
The improvements in health and wellbeing associated with exercise referral schemes aren’t as large as ...
Job search
POST YOUR JOB
Featured supplier news
Featured supplier: Who does your brand belong to?
Who does your brand belong to? There used to be only one answer to this question: the company that grew it and invested in it.
Featured supplier news
Featured supplier: Gympass expands in Ireland with flagship operator Gym Plus
Gympass, a leader in corporate fitness sales, has expanded its network to Ireland following a new partnership with Gym Plus.
Company profiles
Company profile: TRX Training UK
TRX provides world-class functional training by offering quality equipment, effective workouts and world-class education capable ...
Company profiles
Company profile: Balanced Body®
Stocked in the UK for fast, costeffective delivery, Balanced Body® delivers versatile and space-saving mind-body ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Wearable technology solutions
MyZone: Wearable technology solutions
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Skincare
Comfort Zone - Davines S.p.A: Skincare
Trade associations
International SPA Association - iSPA: Trade associations
Direct debit solutions
Harlands Group: Direct debit solutions
Management software
GymSales: Management software
Lockers/interior design
Fitlockers: Lockers/interior design
Locking solutions
Ojmar: Locking solutions
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Property & Tenders
Diary dates
21-23 Jan 2020
Harrogate Convention Centre, Harrogate, United Kingdom
Diary dates
28-30 Jan 2020
Ericsson Exhibition Hall, Ricoh Arena, Coventry, United Kingdom
Diary dates
29-30 Jan 2020
Holiday Inn San Francisco-Golden Gateway, San Francisco, United States
Diary dates
23-25 Mar 2020
Hilton, Barcelona, Spain
Diary dates
25-26 Mar 2020
Eastwood Hall, Nottingham, United Kingdom
Diary dates
19-24 Apr 2020
tbc, Beijing, China
Diary dates
04 Jun 2020
Marriott Forest of Arden Hotel & Country Club, Birmingham, United Kingdom
Diary dates
10-27 Jun 2020
tbc, Pinggu, China
Diary dates
13 Jun 2020
Worldwide, Various,
Diary dates
17-18 Jun 2020
ExCeL London, London, United Kingdom
Diary dates
21-24 Sep 2020
Loews Coronado Bay Resort, Coronado, United States
Diary dates
30-31 Oct 2020
NEC, Birmingham, United Kingdom
Diary dates
Search news, features & products:
Find a supplier:
Les Mills
Les Mills