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Les Mills
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Les Mills
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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

features

Research: Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes

Published in Health Club Management 2020 issue 10
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer

Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

https://www.leisureopportunities.co.uk/images/2020/208955_938109.jpg
A study from the Karolinska Institutet in Sweden suggests exercising can lead to better outcomes in people with cancer
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features

Research: Improved prognosis

New research from the Karolinska Institutet in Sweden, has established why people who exercise when suffering from cancer generally have better outcomes

Published in Health Club Management 2020 issue 10
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
Exercise has been found to improve cancer outcomes / PHOTO: Dragon Images/shutterstock
We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer

Cancer sufferers who exercise regularly have a generally better prognosis than inactive patients, but science hadn’t managed to agree why that is, up to this point.

However, researchers at Karolinska Institutet in Sweden have found a likely explanation of why exercise helps slow down cancer growth.

Randall Johnson, professor at the department of cell and molecular biology at the Karolinska Institutet, says new evidence points to physical activity changing the metabolism of the immune system’s cytotoxic T cells, thereby improving their ability to attack cancer cells.

Johnson is the author of a study – Cytotoxic T-cells mediate exercise-induced reductions in tumor growth – which makes the connection. The work was published in the journal eLife.

“The biology behind the positive effects of exercise can provide new insights into how the body maintains health, as well as helping us design and improve treatments against cancer,” said Johnson.

To examine how exercise influences cancer growth, researchers observed two groups of mice – one which exercised regularly and a another that remained inactive.

T cell activation
They measured levels of common metabolites that are produced in muscle at high levels during exertion.

Some of these metabolites, such as lactate, altered the metabolism of the T cells and increased their activity.

The researchers also found that T cells in the exercising group showed an altered metabolism when compared to T cells from the sedentary group.

During the study, it became clear that cancer cell growth slowed and mortality decreased in the trained group, when compared with the results for the untrained group.

The impact of exercise
Helene Rundqvist, the study’s first author and senior researcher at the department of laboratory medicine at the Karolinska Institutet, said: “Our research shows that exercise affects the production of several molecules and metabolites that activate cancer-fighting immune cells and thereby inhibit cancer growth.

“We hope these results contribute to a deeper understanding of how our lifestyle impacts our immune system and that this work informs the development of new immunotherapies against cancer.”

Find out more about this research at: www.HCMmag.com/TCELLS

https://www.leisureopportunities.co.uk/images/2020/208955_938109.jpg
A study from the Karolinska Institutet in Sweden suggests exercising can lead to better outcomes in people with cancer
Latest News
US fitness industry revenue dropped 58 per cent during 2020 – from the US$35bn all-time ...
Latest News
The UK government is exploring whether incentivising people financially to take part in physical activity ...
Latest News
The Budget announcement has left the UK's physical activity sector with "unanswered questions" and vowing ...
Latest News
Chancellor Rishi Sunak has unveiled an additional £700m funding boost for sports and culture, as ...
Latest News
The merger of two tech firms will result in the creation of a business software ...
Latest News
3d Leisure has put the current lockdown to good use, by stepping in to help ...
Latest News
Gyms and leisure centres in Scotland are set to open on 26 April, provided that ...
Latest News
Hundreds of gyms, swimming pools and leisure centres have been forced to close and thousands ...
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People placing increased emphasis on their physical fitness, the advances made in digital fitness and ...
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Featured supplier: The Retention People unveil 2020 Member Experience Awards winners
Member engagement software provider The Retention People (TRP) has unveiled the winners of its annual 2020 Member Experience Awards (MEA).
Featured supplier news
Featured supplier: Storytelling - the future of fitness content
Heading into 2021, storytelling will be a key trend among fitness content creators and connected fitness providers, as the industry recognises its potential to unlock ultra- engaging experiences that boost retention.
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Mywellness App 5.0
Technogym
Mywellness helps you assess customer needs, provide great workouts and programmes, guarantee a training spot on the gym floor, offer group training, track indoor and outdoor workouts - even with 3rd party apps. Read more
More videos:
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Company profile: Core Health & Fitness
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Catalogue Gallery
Click on a catalogue to view it online
Directory
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Kemitron GmbH: Hydrotherapy / spa fragrances
Spa software
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Fitness equipment
Precor: Fitness equipment
Flooring
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Diary dates
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Expo Centre & Riviera di Rimini, Italy
Diary dates
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Worldwide, Various,
Diary dates
13-14 Jun 2021
Online,
Diary dates
16-17 Jun 2021
ExCeL London, London, United Kingdom
Diary dates
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Diary dates
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Diary dates
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Les Mills
Les Mills