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HCM People: Professor Zhen Yandirector of the Center for Skeletal Muscle Research, University of Virginia

Regular exercise may help people survive COVID-19

Published in Health Club Management 2020 issue 4
Zhen Yan set out to show the physiological impact of exercise on COVID-19 outcomes
Zhen Yan set out to show the physiological impact of exercise on COVID-19 outcomes

Approximately 80 per cent of confirmed COVID-19 patients have mild symptoms, make a good recovery and don’t need respiratory support, while others become extremely unwell and need life support. Professor Zhen Yan at the University of Virginia set out to find out why outcomes are so mixed.

Yan found regular exercise may reduce the risk of complications in people with COVID-19, as well as offering the potential for alternative treatment approaches going forward.

He studied an antioxidant called extracellular superoxide dismutase (EcSOD) that’s released by the muscles and into the bloodstream during exercise.

His work “strongly supports” the possibility that higher levels of EcSOD in the body can prevent or at least reduce the severity of acute respiratory distress syndrome (ARDS) – one of the worst outcomes of the COVID-19 virus.

EcSOD does this by hunting down free radicals, binding to organs and protecting tissues from attack by the virus.

“Our findings strongly support that enhanced EcSOD expression from skeletal muscle…which can be redistributed to lung tissue, could be a viable preventative and therapeutic measure in reducing the risk and severity of ARDS in COVID-19 patients,” he said.

Research suggests that even a single session of exercise increases the production of the antioxidant, prompting Yan to urge people to find ways to exercise, even while maintaining social distancing.

Cardiovascular exercise is thought to drive the highest immediate levels of EcSOD production, however, strength training increases muscle mass, meaning it also plays a part in the equation.

Between three and 17 per cent of people with COVID-19 patients will develop ARDS – this percentage goes up once people are hospitalised to between 20 and 42 per cent, as the more extreme cases succumb to the virus.

“We often say that exercise is medicine. This insight into the role of EcSOD in the body is a perfect example of how we can learn from the biological process of exercise to advance medicine,” Yan said.

“While we strive to learn more about the mysteries of the superb benefits of regular exercise, we don’t have to wait until we know everything before starting to take advantage of this benefit.”

Yan said EcSOD may also prevent multi-organ dysfunction syndrome – in which multiple organs begin to fail.

The antioxidant is also being proposed as a potential therapy for diabetic retinopathy, a complication of diabetes that can lead to blindness.

Low levels of EcSOD are seen in heart disease, kidney failure and osteoarthritis.

Find out more: faculty.virginia.edu/yanlab

Strength training grows muscle mass, increasing the potential for secreting EcSOD
Strength training grows muscle mass, increasing the potential for secreting EcSOD
http://www.leisureopportunities.com/images/2020/945024_195781.jpg
Regular exercise may reduce the risk of complications in people with COVID-19
Professor Zhen Yan, Center for Skeletal Muscle Research, University of Virginia, covid-19,coronavirus,
People
HCM people

Professor Zhen Yan

director of the Center for Skeletal Muscle Research, University of Virginia
Regular exercise may help people survive COVID-19
People
HCM people

Dr Jonathan Leary

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features

HCM People: Professor Zhen Yandirector of the Center for Skeletal Muscle Research, University of Virginia

Regular exercise may help people survive COVID-19

Published in Health Club Management 2020 issue 4
Zhen Yan set out to show the physiological impact of exercise on COVID-19 outcomes
Zhen Yan set out to show the physiological impact of exercise on COVID-19 outcomes

Approximately 80 per cent of confirmed COVID-19 patients have mild symptoms, make a good recovery and don’t need respiratory support, while others become extremely unwell and need life support. Professor Zhen Yan at the University of Virginia set out to find out why outcomes are so mixed.

Yan found regular exercise may reduce the risk of complications in people with COVID-19, as well as offering the potential for alternative treatment approaches going forward.

He studied an antioxidant called extracellular superoxide dismutase (EcSOD) that’s released by the muscles and into the bloodstream during exercise.

His work “strongly supports” the possibility that higher levels of EcSOD in the body can prevent or at least reduce the severity of acute respiratory distress syndrome (ARDS) – one of the worst outcomes of the COVID-19 virus.

EcSOD does this by hunting down free radicals, binding to organs and protecting tissues from attack by the virus.

“Our findings strongly support that enhanced EcSOD expression from skeletal muscle…which can be redistributed to lung tissue, could be a viable preventative and therapeutic measure in reducing the risk and severity of ARDS in COVID-19 patients,” he said.

Research suggests that even a single session of exercise increases the production of the antioxidant, prompting Yan to urge people to find ways to exercise, even while maintaining social distancing.

Cardiovascular exercise is thought to drive the highest immediate levels of EcSOD production, however, strength training increases muscle mass, meaning it also plays a part in the equation.

Between three and 17 per cent of people with COVID-19 patients will develop ARDS – this percentage goes up once people are hospitalised to between 20 and 42 per cent, as the more extreme cases succumb to the virus.

“We often say that exercise is medicine. This insight into the role of EcSOD in the body is a perfect example of how we can learn from the biological process of exercise to advance medicine,” Yan said.

“While we strive to learn more about the mysteries of the superb benefits of regular exercise, we don’t have to wait until we know everything before starting to take advantage of this benefit.”

Yan said EcSOD may also prevent multi-organ dysfunction syndrome – in which multiple organs begin to fail.

The antioxidant is also being proposed as a potential therapy for diabetic retinopathy, a complication of diabetes that can lead to blindness.

Low levels of EcSOD are seen in heart disease, kidney failure and osteoarthritis.

Find out more: faculty.virginia.edu/yanlab

Strength training grows muscle mass, increasing the potential for secreting EcSOD
Strength training grows muscle mass, increasing the potential for secreting EcSOD
http://www.leisureopportunities.com/images/2020/945024_195781.jpg
Regular exercise may reduce the risk of complications in people with COVID-19
Professor Zhen Yan, Center for Skeletal Muscle Research, University of Virginia, covid-19,coronavirus,
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Austrian medical health and wellness operator, Lanserhof, has launched a programme for people who’ve had ...
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HCM can report that Europe Active's annual thought-leader conference, the European Health and Fitness Forum ...
Latest News
The number of people signing up for memberships at Planet Fitness has been at 2019 ...
Latest News
Gyms in England could be open in July if lobbying by the fitness industry comes ...
Latest News
A survey by Savanta ComRes, in partnership with Sport England, has studied the impact of ...
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Gyms and health clubs in the US have begun reopening their doors, with a number ...
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Opinion
promotion
Elon Musk has plans to conquer Mars and these days the meat on your hamburger can be grown in a lab - so why are so many fitness businesses still using papers and pens to create workouts for their members?
Opinion: How the current pandemic may be helping the fitness industry to innovate
Opinion
promotion
The activity industry finds itself in a position of considerable threat. Two-thirds of the world’s gyms are closed – that’s 230 million members unable to attend a fitness facility, according to data platform fitNdata.
Opinion: Ensuring members return after lockdown
Featured supplier news
Featured supplier: Incorpore and MoveGB ink groundbreaking partnership to transform corporate wellness offering
Incorpore and MoveGB have entered into a landmark partnership, combining the UK’s largest provider of corporate gym memberships with the nation’s biggest network of classes.
Featured supplier news
Featured supplier: myFitApp launches branded live-streaming as part of its COVID-19 support package
Innovatise, the company behind myFitApp, has announced the immediate availability of its customer- branded live-streaming solution.
Video Gallery
Technogym mywellness app
Technogym
Improve your training experience. All your data in a single app. Read more
More videos:
Company profiles
Company profile: TVS Group
The TVS Group supply and install sports and fitness flooring to a wide range of ...
Company profiles
Company profile: Keiser UK Ltd
Keiser began its history of visionary sports science leadership over 40 years ago, rejecting the ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Direct debit solutions
Harlands Group: Direct debit solutions
Exercise equipment
Technogym: Exercise equipment
Lockers/interior design
Fitlockers: Lockers/interior design
Management software
Fisikal: Management software
Spa software
SpaBooker: Spa software
Fitness Software
FunXtion International BV: Fitness Software
Gym flooring
REGUPOL/Berleburger Schaumstoffwerk (BSW): Gym flooring
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Zynk Design Consultants: Design consultants
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International SPA Association - iSPA: Trade associations
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Greywell, Hampshire
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Diary dates
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Marriott Forest of Arden Hotel & Country Club, Birmingham, United Kingdom
Diary dates
13 Jun 2020
Worldwide, Various,
Diary dates
06-07 Jul 2020
Eastwood Hall, Nottingham, United Kingdom
Diary dates
28-31 Aug 2020
Expo Centre & Riviera di Rimini, Italy
Diary dates
21-24 Sep 2020
Loews Coronado Bay Resort, Coronado, United States
Diary dates
11-12 Oct 2020
ExCeL London, London, United Kingdom
Diary dates
17-23 Oct 2020
Pinggu, Beijing, China
Diary dates
27-30 Oct 2020
Messe Stuttgart, Germany
Diary dates
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NEC, Birmingham, United Kingdom
Diary dates
27-28 Nov 2020
Athena, Leicester, United Kingdom
Diary dates
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