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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

features

Research: Exercise reduces risk of disease by changing DNA

Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen

Published in Health Club Management 2021 issue 8
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
The beneficial changes to the brain – prompted by exercise – protect against the development of various diseases due to signals release by muscles into the bloodstream

Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease by driving epigenetic changes in the body.

The finding comes from a study by the University of Copenhagen which reveals how exercise remodels the DNA in skeletal muscle, so new signals are established to keep the body healthy.

While it’s known that regular physical exercise decreases the risk of virtually all chronic illnesses, the mechanisms at play have not been fully understood. The discovery suggests the beneficial effects of physical exercise may – in part – come from the epigenetic changes they prompt.

The research team studied a group of healthy young men through a six-week endurance exercise programme.

A biopsy of participants’ thigh muscle was collected before and after the exercise intervention and examined to see whether changes in the epigenetic signature of their DNA occurred as a result of training.

Structure of muscle
Scientists discovered that after completing the endurance training programme, the structure of many enhancers in the skeletal muscle had been altered.

By connecting these enhancers to series of genetic databases, they discovered that many of the regulated enhancers have already been identified by researchers as ‘hotspots’ that have been associated with human disease. These beneficial changes – prompted by exercise – are thought to protect against the development of various diseases.

Brain benefits
The researchers also found that exercise benefited organs that are distant from muscle, such as the brain – they speculate that these additional benefits might have come about as a result of signals released by muscles into the bloodstream.

Epigenetic links
Kristine Williams, lead author of the study, said: “Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.”

The research was published in the journal Molecular Metabolism.

Professor Romain Barrès, senior author, added: “Our findings provide a mechanism for the known beneficial effects of exercise.

“By connecting each enhancer with a gene, we further provide a list of direct targets that could mediate this effect.”

More: www.HCMmag.com/epigenetic

https://www.leisureopportunities.co.uk/images/2021/26667_490676.jpg
Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease
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Diary dates
07-10 Apr 2022
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Diary dates
15-16 Jun 2022
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Diary dates

features

Research: Exercise reduces risk of disease by changing DNA

Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen

Published in Health Club Management 2021 issue 8
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
The beneficial changes to the brain – prompted by exercise – protect against the development of various diseases due to signals release by muscles into the bloodstream

Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease by driving epigenetic changes in the body.

The finding comes from a study by the University of Copenhagen which reveals how exercise remodels the DNA in skeletal muscle, so new signals are established to keep the body healthy.

While it’s known that regular physical exercise decreases the risk of virtually all chronic illnesses, the mechanisms at play have not been fully understood. The discovery suggests the beneficial effects of physical exercise may – in part – come from the epigenetic changes they prompt.

The research team studied a group of healthy young men through a six-week endurance exercise programme.

A biopsy of participants’ thigh muscle was collected before and after the exercise intervention and examined to see whether changes in the epigenetic signature of their DNA occurred as a result of training.

Structure of muscle
Scientists discovered that after completing the endurance training programme, the structure of many enhancers in the skeletal muscle had been altered.

By connecting these enhancers to series of genetic databases, they discovered that many of the regulated enhancers have already been identified by researchers as ‘hotspots’ that have been associated with human disease. These beneficial changes – prompted by exercise – are thought to protect against the development of various diseases.

Brain benefits
The researchers also found that exercise benefited organs that are distant from muscle, such as the brain – they speculate that these additional benefits might have come about as a result of signals released by muscles into the bloodstream.

Epigenetic links
Kristine Williams, lead author of the study, said: “Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.”

The research was published in the journal Molecular Metabolism.

Professor Romain Barrès, senior author, added: “Our findings provide a mechanism for the known beneficial effects of exercise.

“By connecting each enhancer with a gene, we further provide a list of direct targets that could mediate this effect.”

More: www.HCMmag.com/epigenetic

https://www.leisureopportunities.co.uk/images/2021/26667_490676.jpg
Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease
Latest News
Denmark has been identified as the cheapest country in the world to live a healthy ...
Latest News
Boxx has launched a new generation punch bag and smart punch trackers that work with ...
Latest News
The Global Wellness Institute (GWI) and BBC Storyworks have struck up a partnership to create ...
Latest News
The global wellness economy will grow by 9.9 per cent annually and reach US$7trn by ...
Latest News
Inclusive Fitness Boston, a health club created specifically for those with disabilities and their families, ...
Latest News
The Women in Fitness Association (WIFA), is partnering with Sport Alliance to undertake a survey ...
Latest News
Location and cost are the top considerations for consumers when it comes to choosing a ...
Latest News
Increases in COVID-19 cases across Europe are forcing governments to introduce restrictions, which is having ...
Latest News
Exercise has been found to increase levels of endocannabinoids – cannabis-like substances produced by the ...
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People suffering from mild depression should be offered exercise, mindfulness, therapy or meditation before medication, ...
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Total Fitness plans to launch a new-style health club model, with plans already in the ...
Opinion
promotion
FitnessOnDemand’s divisional vice president Uday Anumalachetty discusses what live fitness really means for clubs and their members today
Opinion: Why we need to reimagine what live fitness really means
Featured supplier news
Featured supplier news: 1Rebel enlists FunXtion to elevate its revolutionary, customer-driven RIG concept
A partnership with FunXtion and its MultiScreen Solution software has allowed 1Rebel to enhance its in-club experience to a much more connected and engaged level.
Featured supplier news
Featured supplier news: First énergie site opens in Barcelona fully equipped by Core Health & Fitness
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Featured operator news: Everyone Active successfully reopens exercise referral scheme thanks to EXi partnership
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Company profiles
Company profile: Magicline GmbH
For more than 30 years, Magicline has been driving the digitalisation of the fitness industry ...
Company profiles
Company profile: EGYM UK Ltd
EGYM empowers gym operators to deliver a workout experience that supports their members' lifelong fitness ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Lockers/interior design
Safe Space Lockers Ltd: Lockers/interior design
Exercise equipment
Power Plate: Exercise equipment
Spa software
SpaBooker: Spa software
Red Light Therapy
 Red Light Rising: Red Light Therapy
Salt therapy products
Saltability: Salt therapy products
Wearable technology solutions
MyZone: Wearable technology solutions
Management software
Premier Software Solutions: Management software
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Skincare
Sothys: Skincare
Fitness equipment
Octane Fitness: Fitness equipment
Property & Tenders
Welwyn Garden City
Welwyn Hatfield Borough Council
Property & Tenders
Newport, Shropshire
Lilleshall Sports Academy
Property & Tenders
Diary dates
01-03 Feb 2022
Coventry Building Society Arena, Coventry, United Kingdom
Diary dates
07-10 Apr 2022
Exhibition Centre , Cologne, Germany
Diary dates
15-16 Jun 2022
ExCeL London, London, United Kingdom
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates
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