Zimmer MedizinSysteme GmbH / icelab
Zimmer MedizinSysteme GmbH / icelab
Zimmer MedizinSysteme GmbH / icelab
Health Club Management

Health Club Management

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Health Club Management

Health Club Management

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Cellular clean-up

US scientists have identified a new benefit of exercise – its ability to help remove cellular debris from the body

Published in Health Club Management 2014 issue 3

In a new discovery, scientists at the US University of Virginia School of Medicine have found that exercise aids a cellular cleaning process in the body known as autophagy. The research, which was based on mice, was published in the bioscience title The FASEB Journal* and showed that exercise increases the ability of skeletal muscle cells to remove damaged components and other cellular debris by this cleaning process. In turn, autophagy is vital for muscles to adapt to exercise – and for the body to receive the health benefits of working out.

The findings could prove important in the battle against the effect of ageing and in diseases like diabetes. They could also shed some light on why some people see little benefit from exercise. We explain the science behind this below.

A body janitor
It’s well known that daily wear and tear on the body’s cells leads to broken or misshaped components. Autophagy, or ‘self-eating’, is the process by which cells clear up this flotsam. Study researcher Dr Zhen Yan explains: “If I can use an analogy to describe this [cellular clean-up process], it’s like daily cleaning by janitors. A team of janitors comes to clean up the working environment, to maintain the homeostasis of the cell.”

Without this process, cells can become blocked, malfunction or die. Some scientists are even beginning to link faulty autophagy function to diseases such as diabetes, cancer and Alzheimer’s. It’s thought that the slowing of this mechanism as we become older also has a part to play in the ageing process.

Yan refers to his analogy to explain: “Exercise training seems to increase the number of janitors and make the process more efficient. So we have a more active cleaning process of the cell.”

The exercise effect
Autophagy was first discovered as a result of stress that comes from cell starvation. A cell recycles some components to help keep the rest of itself alive, but when it’s starved or under physiological stress – like exercise – the autophagy process speeds up.

Yan tells HCM: “Muscles that are frequently used for locomotion or other activities and endurance (four-week) exercise-trained muscles have higher basal level autophagy and more proteins with function in autophagy than muscles that are rarely used.”

The study complements 2012 research by the University of Texas Southwestern, US, which suggests that an acute (30 minute) bout of exercise activated accelerated autography.

Impact on muscle
What Yan and his colleagues also discovered, is that if there’s a problem with the cellular cleaning process, the muscle may not be able to adapt to exercise in order to improve performance. This could mean “losing the trainability”, he explains. It could also, in turn, “impact the effect of exercise in dealing with metabolic diseases such as diabetes”.

According to Yan’s fellow researcher Vitro A Lira, it’s also possible that limitations in autophagy could explain why some people reap the benefits of exercise while others don’t. Although this has yet to be proven.

A new direction
The findings could lead to ways to simulate the benefits of exercise on the cellular cleansing process, such as with a drug. This could benefit people who do not respond to exercise or cannot exercise. It could also help with the slowing of the cellular cleansing process that comes with age – a slowing that causes loss of muscle mass and strength and impaired metabolism.

*Lira V et al. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. The FASEB Journal, June 2013

http://www.leisureopportunities.com/images/HCM2014_3cellur.gif
US scientists have discovered a new benefit of exercise: its ability to remove debris in the body
People
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features

Cellular clean-up

US scientists have identified a new benefit of exercise – its ability to help remove cellular debris from the body

Published in Health Club Management 2014 issue 3

In a new discovery, scientists at the US University of Virginia School of Medicine have found that exercise aids a cellular cleaning process in the body known as autophagy. The research, which was based on mice, was published in the bioscience title The FASEB Journal* and showed that exercise increases the ability of skeletal muscle cells to remove damaged components and other cellular debris by this cleaning process. In turn, autophagy is vital for muscles to adapt to exercise – and for the body to receive the health benefits of working out.

The findings could prove important in the battle against the effect of ageing and in diseases like diabetes. They could also shed some light on why some people see little benefit from exercise. We explain the science behind this below.

A body janitor
It’s well known that daily wear and tear on the body’s cells leads to broken or misshaped components. Autophagy, or ‘self-eating’, is the process by which cells clear up this flotsam. Study researcher Dr Zhen Yan explains: “If I can use an analogy to describe this [cellular clean-up process], it’s like daily cleaning by janitors. A team of janitors comes to clean up the working environment, to maintain the homeostasis of the cell.”

Without this process, cells can become blocked, malfunction or die. Some scientists are even beginning to link faulty autophagy function to diseases such as diabetes, cancer and Alzheimer’s. It’s thought that the slowing of this mechanism as we become older also has a part to play in the ageing process.

Yan refers to his analogy to explain: “Exercise training seems to increase the number of janitors and make the process more efficient. So we have a more active cleaning process of the cell.”

The exercise effect
Autophagy was first discovered as a result of stress that comes from cell starvation. A cell recycles some components to help keep the rest of itself alive, but when it’s starved or under physiological stress – like exercise – the autophagy process speeds up.

Yan tells HCM: “Muscles that are frequently used for locomotion or other activities and endurance (four-week) exercise-trained muscles have higher basal level autophagy and more proteins with function in autophagy than muscles that are rarely used.”

The study complements 2012 research by the University of Texas Southwestern, US, which suggests that an acute (30 minute) bout of exercise activated accelerated autography.

Impact on muscle
What Yan and his colleagues also discovered, is that if there’s a problem with the cellular cleaning process, the muscle may not be able to adapt to exercise in order to improve performance. This could mean “losing the trainability”, he explains. It could also, in turn, “impact the effect of exercise in dealing with metabolic diseases such as diabetes”.

According to Yan’s fellow researcher Vitro A Lira, it’s also possible that limitations in autophagy could explain why some people reap the benefits of exercise while others don’t. Although this has yet to be proven.

A new direction
The findings could lead to ways to simulate the benefits of exercise on the cellular cleansing process, such as with a drug. This could benefit people who do not respond to exercise or cannot exercise. It could also help with the slowing of the cellular cleansing process that comes with age – a slowing that causes loss of muscle mass and strength and impaired metabolism.

*Lira V et al. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. The FASEB Journal, June 2013

http://www.leisureopportunities.com/images/HCM2014_3cellur.gif
US scientists have discovered a new benefit of exercise: its ability to remove debris in the body
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DW Fitness First has extended its partnership with corporate fitness sales specialist Gympass, to increase ...
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Featured supplier: Training provider explains how a partnership with Fisikal transformed their business
Drummond Health & Fitness Education Academy has been providing quality health and fitness training and education for more than 35 years.
Featured supplier news
Featured supplier: active-net unveils Gen Z-themed agenda
Active-net 2020 has revealed the agenda for the two-day educational, networking and business meetings event, which takes place next month.
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Wattbike AtomX
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Join our tribe. Become powered by Wattbike. Read more
More videos:
Company profiles
Company profile: Netpulse
Founded in 2001, Netpulse is the world’s number one provider of branded mobile apps for ...
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Company profile: Stages Indoor Cycling
Stages Indoor Cycling is a product and technology company that is 100% focused on creating ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Gym flooring
REGUPOL/Berleburger Schaumstoffwerk (BSW): Gym flooring
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Direct debit solutions
Debit Finance Collections: Direct debit solutions
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International SPA Association - iSPA: Trade associations
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Kemitron GmbH: Hydrotherapy / spa fragrances
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Go Do.Fitness: Fitness software
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Palazzo del Ghiaccio, Milan, Italy
Diary dates
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Hilton, Barcelona, Spain
Diary dates
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Executive Boardroom, Middlesex University, London, United Kingdom
Diary dates
25-26 Mar 2020
Eastwood Hall, Nottingham, United Kingdom
Diary dates
26-29 Mar 2020
The Winter Gardens Blackpool, Blackpool , United Kingdom
Diary dates
27-29 Mar 2020
TeatroGoya Multiespacio, Madrid, Spain
Diary dates
19-24 Apr 2020
tbc, Beijing, China
Diary dates
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Marriott Forest of Arden Hotel & Country Club, Birmingham, United Kingdom
Diary dates
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Worldwide, Various,
Diary dates
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ExCeL London, London, United Kingdom
Diary dates
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Diary dates
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Diary dates
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Diary dates
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Diary dates
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