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Health Club Management

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Cellular clean-up

US scientists have identified a new benefit of exercise – its ability to help remove cellular debris from the body

Published in Health Club Management 2014 issue 3

In a new discovery, scientists at the US University of Virginia School of Medicine have found that exercise aids a cellular cleaning process in the body known as autophagy. The research, which was based on mice, was published in the bioscience title The FASEB Journal* and showed that exercise increases the ability of skeletal muscle cells to remove damaged components and other cellular debris by this cleaning process. In turn, autophagy is vital for muscles to adapt to exercise – and for the body to receive the health benefits of working out.

The findings could prove important in the battle against the effect of ageing and in diseases like diabetes. They could also shed some light on why some people see little benefit from exercise. We explain the science behind this below.

A body janitor
It’s well known that daily wear and tear on the body’s cells leads to broken or misshaped components. Autophagy, or ‘self-eating’, is the process by which cells clear up this flotsam. Study researcher Dr Zhen Yan explains: “If I can use an analogy to describe this [cellular clean-up process], it’s like daily cleaning by janitors. A team of janitors comes to clean up the working environment, to maintain the homeostasis of the cell.”

Without this process, cells can become blocked, malfunction or die. Some scientists are even beginning to link faulty autophagy function to diseases such as diabetes, cancer and Alzheimer’s. It’s thought that the slowing of this mechanism as we become older also has a part to play in the ageing process.

Yan refers to his analogy to explain: “Exercise training seems to increase the number of janitors and make the process more efficient. So we have a more active cleaning process of the cell.”

The exercise effect
Autophagy was first discovered as a result of stress that comes from cell starvation. A cell recycles some components to help keep the rest of itself alive, but when it’s starved or under physiological stress – like exercise – the autophagy process speeds up.

Yan tells HCM: “Muscles that are frequently used for locomotion or other activities and endurance (four-week) exercise-trained muscles have higher basal level autophagy and more proteins with function in autophagy than muscles that are rarely used.”

The study complements 2012 research by the University of Texas Southwestern, US, which suggests that an acute (30 minute) bout of exercise activated accelerated autography.

Impact on muscle
What Yan and his colleagues also discovered, is that if there’s a problem with the cellular cleaning process, the muscle may not be able to adapt to exercise in order to improve performance. This could mean “losing the trainability”, he explains. It could also, in turn, “impact the effect of exercise in dealing with metabolic diseases such as diabetes”.

According to Yan’s fellow researcher Vitro A Lira, it’s also possible that limitations in autophagy could explain why some people reap the benefits of exercise while others don’t. Although this has yet to be proven.

A new direction
The findings could lead to ways to simulate the benefits of exercise on the cellular cleansing process, such as with a drug. This could benefit people who do not respond to exercise or cannot exercise. It could also help with the slowing of the cellular cleansing process that comes with age – a slowing that causes loss of muscle mass and strength and impaired metabolism.

*Lira V et al. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. The FASEB Journal, June 2013

http://www.leisureopportunities.com/images/HCM2014_3cellur.gif
US scientists have discovered a new benefit of exercise: its ability to remove debris in the body
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features

Cellular clean-up

US scientists have identified a new benefit of exercise – its ability to help remove cellular debris from the body

Published in Health Club Management 2014 issue 3

In a new discovery, scientists at the US University of Virginia School of Medicine have found that exercise aids a cellular cleaning process in the body known as autophagy. The research, which was based on mice, was published in the bioscience title The FASEB Journal* and showed that exercise increases the ability of skeletal muscle cells to remove damaged components and other cellular debris by this cleaning process. In turn, autophagy is vital for muscles to adapt to exercise – and for the body to receive the health benefits of working out.

The findings could prove important in the battle against the effect of ageing and in diseases like diabetes. They could also shed some light on why some people see little benefit from exercise. We explain the science behind this below.

A body janitor
It’s well known that daily wear and tear on the body’s cells leads to broken or misshaped components. Autophagy, or ‘self-eating’, is the process by which cells clear up this flotsam. Study researcher Dr Zhen Yan explains: “If I can use an analogy to describe this [cellular clean-up process], it’s like daily cleaning by janitors. A team of janitors comes to clean up the working environment, to maintain the homeostasis of the cell.”

Without this process, cells can become blocked, malfunction or die. Some scientists are even beginning to link faulty autophagy function to diseases such as diabetes, cancer and Alzheimer’s. It’s thought that the slowing of this mechanism as we become older also has a part to play in the ageing process.

Yan refers to his analogy to explain: “Exercise training seems to increase the number of janitors and make the process more efficient. So we have a more active cleaning process of the cell.”

The exercise effect
Autophagy was first discovered as a result of stress that comes from cell starvation. A cell recycles some components to help keep the rest of itself alive, but when it’s starved or under physiological stress – like exercise – the autophagy process speeds up.

Yan tells HCM: “Muscles that are frequently used for locomotion or other activities and endurance (four-week) exercise-trained muscles have higher basal level autophagy and more proteins with function in autophagy than muscles that are rarely used.”

The study complements 2012 research by the University of Texas Southwestern, US, which suggests that an acute (30 minute) bout of exercise activated accelerated autography.

Impact on muscle
What Yan and his colleagues also discovered, is that if there’s a problem with the cellular cleaning process, the muscle may not be able to adapt to exercise in order to improve performance. This could mean “losing the trainability”, he explains. It could also, in turn, “impact the effect of exercise in dealing with metabolic diseases such as diabetes”.

According to Yan’s fellow researcher Vitro A Lira, it’s also possible that limitations in autophagy could explain why some people reap the benefits of exercise while others don’t. Although this has yet to be proven.

A new direction
The findings could lead to ways to simulate the benefits of exercise on the cellular cleansing process, such as with a drug. This could benefit people who do not respond to exercise or cannot exercise. It could also help with the slowing of the cellular cleansing process that comes with age – a slowing that causes loss of muscle mass and strength and impaired metabolism.

*Lira V et al. Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance. The FASEB Journal, June 2013

http://www.leisureopportunities.com/images/HCM2014_3cellur.gif
US scientists have discovered a new benefit of exercise: its ability to remove debris in the body
Latest News
New York’s Blum Center for Health, a functional health facility, is offering a personalised, non-invasive, ...
Latest News
US-based fitness franchise UFC Gym has opened its first European club. The 18,000sq ft (1,670sq ...
Latest News
Public Health England (PHE) and the Centre for Ageing Better (CAB) have set out their ...
Latest News
Physical activity bodies ukactive and EuropeActive have agreed to strengthen their partnership in the event ...
Latest News
The first-ever FIBO Southeast Asia fitness event will be held in Singapore next year. Taking ...
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Featured supplier: Fisikal develops new 'easy start' business management solution for studios and personal trainers
Fisikal has launched its first self-activating digital business solution, ideal for personal trainers and studio operators.
Featured supplier news
Featured supplier: Crown Sports Lockers to launch sector first at IHS 2019
Crown Sports Locker will launch a waterproof locker that will open the door to facilities demanding a sustainable solution for wet changing areas.
Opinion
promotion
An ever-increasing number of Brits are engaging in sporting events, setting themselves goals and looking to increase their fitness levels....
Opinion: Dr Crionna Tobin on nutritional training for PTs and fitness experts
As an industry, we still underestimate the power of a truly varied fitness regime - and the growing appetite for it, especially among emerging customer segments.
Opinion: Collaboration vs aggregation - what’s the difference?
Company profiles
Company profile: Precor
For more than 35 years, Precor has driven fitness forward. We continue that heritage every ...
Company profiles
Company profile: Power Plate
Power Plate is a vibrating platform that enhances any movement to help you prepare faster, ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Skincare
Comfort Zone - Davines S.p.A: Skincare
Locking solutions
Ojmar: Locking solutions
Direct debit solutions
Harlands Group: Direct debit solutions
Fitness equipment
Dyaco International: Fitness equipment
Fitness software
Go Do.Fitness: Fitness software
Wearable technology solutions
MyZone: Wearable technology solutions
Whole body cryotherapy
Zimmer MedizinSysteme GmbH / icelab: Whole body cryotherapy
Lockers/interior design
Fitlockers: Lockers/interior design
Member access schemes
Move GB: Member access schemes
Audio visual
Hutchison Technologies: Audio visual
Property & Tenders
Kirklees Active Leisure
Property & Tenders
Diary dates
28-30 Oct 2019
Hotel Royal Savoy, Lausanne, Switzerland
Diary dates
30-31 Oct 2019
NEC, Birmingham, United Kingdom
Diary dates
05-08 Nov 2019
Koelnmesse, Cologne, Germany
Diary dates
21-22 Nov 2019
JW Marriott Miami Turnberry Resort, Aventura,
Diary dates
29 Nov 2019
The King’s Fund, London, United Kingdom
Diary dates
29-30 Jan 2020
Holiday Inn San Francisco-Golden Gateway, San Francisco, United States
Diary dates
23-25 Mar 2020
Hilton, Barcelona, Spain
Diary dates
10-27 Jun 2020
tbc, Pinggu, China
Diary dates
17-18 Jun 2020
ExCeL London, London, United Kingdom
Diary dates
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