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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

features

Research: Exercise reduces risk of disease by changing DNA

Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen

Published in Health Club Management 2021 issue 8
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
The beneficial changes to the brain – prompted by exercise – protect against the development of various diseases due to signals release by muscles into the bloodstream

Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease by driving epigenetic changes in the body.

The finding comes from a study by the University of Copenhagen which reveals how exercise remodels the DNA in skeletal muscle, so new signals are established to keep the body healthy.

While it’s known that regular physical exercise decreases the risk of virtually all chronic illnesses, the mechanisms at play have not been fully understood. The discovery suggests the beneficial effects of physical exercise may – in part – come from the epigenetic changes they prompt.

The research team studied a group of healthy young men through a six-week endurance exercise programme.

A biopsy of participants’ thigh muscle was collected before and after the exercise intervention and examined to see whether changes in the epigenetic signature of their DNA occurred as a result of training.

Structure of muscle
Scientists discovered that after completing the endurance training programme, the structure of many enhancers in the skeletal muscle had been altered.

By connecting these enhancers to series of genetic databases, they discovered that many of the regulated enhancers have already been identified by researchers as ‘hotspots’ that have been associated with human disease. These beneficial changes – prompted by exercise – are thought to protect against the development of various diseases.

Brain benefits
The researchers also found that exercise benefited organs that are distant from muscle, such as the brain – they speculate that these additional benefits might have come about as a result of signals released by muscles into the bloodstream.

Epigenetic links
Kristine Williams, lead author of the study, said: “Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.”

The research was published in the journal Molecular Metabolism.

Professor Romain Barrès, senior author, added: “Our findings provide a mechanism for the known beneficial effects of exercise.

“By connecting each enhancer with a gene, we further provide a list of direct targets that could mediate this effect.”

More: www.HCMmag.com/epigenetic

https://www.leisureopportunities.co.uk/images/2021/26667_490676.jpg
Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease
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Research
Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen
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Click on a catalogue to view it online
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Diary dates
01-03 Feb 2022
Coventry Building Society Arena, Coventry, United Kingdom
Diary dates
07-10 Apr 2022
Exhibition Centre , Cologne, Germany
Diary dates
15-16 Jun 2022
ExCeL London, London, United Kingdom
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates

features

Research: Exercise reduces risk of disease by changing DNA

Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen

Published in Health Club Management 2021 issue 8
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
The beneficial changes to the brain – prompted by exercise – protect against the development of various diseases due to signals release by muscles into the bloodstream

Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease by driving epigenetic changes in the body.

The finding comes from a study by the University of Copenhagen which reveals how exercise remodels the DNA in skeletal muscle, so new signals are established to keep the body healthy.

While it’s known that regular physical exercise decreases the risk of virtually all chronic illnesses, the mechanisms at play have not been fully understood. The discovery suggests the beneficial effects of physical exercise may – in part – come from the epigenetic changes they prompt.

The research team studied a group of healthy young men through a six-week endurance exercise programme.

A biopsy of participants’ thigh muscle was collected before and after the exercise intervention and examined to see whether changes in the epigenetic signature of their DNA occurred as a result of training.

Structure of muscle
Scientists discovered that after completing the endurance training programme, the structure of many enhancers in the skeletal muscle had been altered.

By connecting these enhancers to series of genetic databases, they discovered that many of the regulated enhancers have already been identified by researchers as ‘hotspots’ that have been associated with human disease. These beneficial changes – prompted by exercise – are thought to protect against the development of various diseases.

Brain benefits
The researchers also found that exercise benefited organs that are distant from muscle, such as the brain – they speculate that these additional benefits might have come about as a result of signals released by muscles into the bloodstream.

Epigenetic links
Kristine Williams, lead author of the study, said: “Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.”

The research was published in the journal Molecular Metabolism.

Professor Romain Barrès, senior author, added: “Our findings provide a mechanism for the known beneficial effects of exercise.

“By connecting each enhancer with a gene, we further provide a list of direct targets that could mediate this effect.”

More: www.HCMmag.com/epigenetic

https://www.leisureopportunities.co.uk/images/2021/26667_490676.jpg
Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease
Latest News
The pandemic has had an "unprecedented" impact on physical activity levels in England, with 1 ...
Latest News
The first énergie Fitness club has opened in Spain as part of a push for ...
Latest News
A global innovation competition has been launched to find ways to encourage and support more ...
Latest News
Xponential Fitness has acquired Body Fit Training in a deal worth US$44m. The deal takes ...
Latest News
Exercise has been highlighted as a crucial weapon in cancer patients’ battle against the disease. ...
Latest News
The global health and fitness industry is returning to a busy programme of live trade ...
Latest News
Matrix and Intelivideo have signed a strategic partnership, which will see Intelivideo's fitness content integrated ...
Latest News
Nadine Dorries, the recently appointed secretary of state for digital, culture, media and sport at ...
Latest News
Mindbody has announced it's buying ClassPass, the consumer wellness subscription service that enables people to ...
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Tanni Grey-Thompson has outlined her vision on how the physical activity sector can play "the ...
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The Global Health & Fitness Alliance (GHFA) has revealed the makeup of its inaugural nine-member ...
Featured supplier news
Featured supplier news: Will your business last without digital transformation?
During the pandemic, a digital transformation took off faster than anyone could have predicted with meetings in person cancelled and millions working from home.
Featured supplier news
Featured supplier news: GLL Better UK App passes 1 million downloads
GLL and its app partner Innovatise (myFitApp) have today announced the Better UK App has been downloaded over 1 million times since it was launched in November 2019.
Featured operator news
Featured operator news: Sporting heroes to officially open £22 million redevelopment at Everyone Active centre
A £22 million redevelopment project will be unveiled at Grange Paddocks Leisure Centre, as part of the official launch of the state-of-the-art centre.
Featured operator news
Featured operator news: Being active helps Parkwood Leisure customers save the NHS £16m
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Company profiles
Company profile: Merrithew™ - Leaders in Mindful Movement™
Merrithew™ enriches the lives of others with responsible exercise modalities and innovative, multidisciplinary fitness offerings ...
Company profiles
Company profile: Gympass
On a mission to defeat inactivity, Gympass is a corporate wellness solution that builds mutually ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Uniforms
Service Sport: Uniforms
Red Light Therapy
 Red Light Rising: Red Light Therapy
Architects/designers
Zynk Design Consultants: Architects/designers
Independent service & maintenance
Servicesport UK Limited: Independent service & maintenance
Spa software
SpaBooker: Spa software
Management software
Premier Software Solutions: Management software
Whole body cryotherapy
Art of Cryo: Whole body cryotherapy
Exercise equipment
Matrix Fitness: Exercise equipment
Wearable technology solutions
MyZone: Wearable technology solutions
Lockers/interior design
Fitlockers: Lockers/interior design
Property & Tenders
Welwyn Garden City
Welwyn Hatfield Borough Council
Property & Tenders
Newport, Shropshire
Lilleshall Sports Academy
Property & Tenders
Diary dates
01-03 Feb 2022
Coventry Building Society Arena, Coventry, United Kingdom
Diary dates
07-10 Apr 2022
Exhibition Centre , Cologne, Germany
Diary dates
15-16 Jun 2022
ExCeL London, London, United Kingdom
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates
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