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JP Lennard
JP Lennard
JP Lennard
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UNITING THE WORLD OF FITNESS
Health Club Management

Health Club Management

features

Research: Exercise reduces risk of disease by changing DNA

Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen

Published in Health Club Management 2021 issue 8
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
The beneficial changes to the brain – prompted by exercise – protect against the development of various diseases due to signals release by muscles into the bloodstream

Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease by driving epigenetic changes in the body.

The finding comes from a study by the University of Copenhagen which reveals how exercise remodels the DNA in skeletal muscle, so new signals are established to keep the body healthy.

While it’s known that regular physical exercise decreases the risk of virtually all chronic illnesses, the mechanisms at play have not been fully understood. The discovery suggests the beneficial effects of physical exercise may – in part – come from the epigenetic changes they prompt.

The research team studied a group of healthy young men through a six-week endurance exercise programme.

A biopsy of participants’ thigh muscle was collected before and after the exercise intervention and examined to see whether changes in the epigenetic signature of their DNA occurred as a result of training.

Structure of muscle
Scientists discovered that after completing the endurance training programme, the structure of many enhancers in the skeletal muscle had been altered.

By connecting these enhancers to series of genetic databases, they discovered that many of the regulated enhancers have already been identified by researchers as ‘hotspots’ that have been associated with human disease. These beneficial changes – prompted by exercise – are thought to protect against the development of various diseases.

Brain benefits
The researchers also found that exercise benefited organs that are distant from muscle, such as the brain – they speculate that these additional benefits might have come about as a result of signals released by muscles into the bloodstream.

Epigenetic links
Kristine Williams, lead author of the study, said: “Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.”

The research was published in the journal Molecular Metabolism.

Professor Romain Barrès, senior author, added: “Our findings provide a mechanism for the known beneficial effects of exercise.

“By connecting each enhancer with a gene, we further provide a list of direct targets that could mediate this effect.”

More: www.HCMmag.com/epigenetic

https://www.leisureopportunities.co.uk/images/2021/26667_490676.jpg
Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease
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Diary dates
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Diary dates
15-16 Jun 2022
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tbc, Dunedin, New Zealand
Diary dates

features

Research: Exercise reduces risk of disease by changing DNA

Changes to DNA which occur during exercise give protection against a wide range of diseases, according to new research from the Univesity of Copenhagen

Published in Health Club Management 2021 issue 8
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
Scientists found regular exercise drives positive epigenetic changes in the body / wavebreak media /shutterstock
The beneficial changes to the brain – prompted by exercise – protect against the development of various diseases due to signals release by muscles into the bloodstream

Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease by driving epigenetic changes in the body.

The finding comes from a study by the University of Copenhagen which reveals how exercise remodels the DNA in skeletal muscle, so new signals are established to keep the body healthy.

While it’s known that regular physical exercise decreases the risk of virtually all chronic illnesses, the mechanisms at play have not been fully understood. The discovery suggests the beneficial effects of physical exercise may – in part – come from the epigenetic changes they prompt.

The research team studied a group of healthy young men through a six-week endurance exercise programme.

A biopsy of participants’ thigh muscle was collected before and after the exercise intervention and examined to see whether changes in the epigenetic signature of their DNA occurred as a result of training.

Structure of muscle
Scientists discovered that after completing the endurance training programme, the structure of many enhancers in the skeletal muscle had been altered.

By connecting these enhancers to series of genetic databases, they discovered that many of the regulated enhancers have already been identified by researchers as ‘hotspots’ that have been associated with human disease. These beneficial changes – prompted by exercise – are thought to protect against the development of various diseases.

Brain benefits
The researchers also found that exercise benefited organs that are distant from muscle, such as the brain – they speculate that these additional benefits might have come about as a result of signals released by muscles into the bloodstream.

Epigenetic links
Kristine Williams, lead author of the study, said: “Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.”

The research was published in the journal Molecular Metabolism.

Professor Romain Barrès, senior author, added: “Our findings provide a mechanism for the known beneficial effects of exercise.

“By connecting each enhancer with a gene, we further provide a list of direct targets that could mediate this effect.”

More: www.HCMmag.com/epigenetic

https://www.leisureopportunities.co.uk/images/2021/26667_490676.jpg
Researchers have established that regular exercise changes the DNA of skeletal muscle cells, reducing the risk of disease
Latest News
The Women in Fitness Association (WIFA), is partnering with Sport Alliance to undertake a survey ...
Latest News
Location and cost are the top considerations for consumers when it comes to choosing a ...
Latest News
Increases in COVID-19 cases across Europe are forcing governments to introduce restrictions, which is having ...
Latest News
Exercise has been found to increase levels of endocannabinoids – cannabis-like substances produced by the ...
Latest News
People suffering from mild depression should be offered exercise, mindfulness, therapy or meditation before medication, ...
Latest News
Total Fitness plans to launch a new-style health club model, with plans already in the ...
Latest News
Fitness operator Crunch Fitness says it's continued its recovery from lockdowns, with membership levels across ...
Latest News
The City of Madrid could become one of the healthiest in the world if plans ...
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Luxury health club operator, Third Space, has opened the doors to its latest club in ...
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A total of 22.7 million Brits – more than a third of the total population ...
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Opinion
promotion
FitnessOnDemand’s divisional vice president Uday Anumalachetty discusses what live fitness really means for clubs and their members today
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Featured supplier news
Featured supplier news: Pulse Fitness appointed as preferred fitness supplier to Telford & Wrekin Leisure
After winning a competitive tender process in 2019, Pulse Fitness was appointed by Telford & Wrekin Leisure as its preferred fitness supplier over the next five years.
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Featured supplier news: Revamped Fitline Maassluis health club equipped by Core Health & Fitness
An iconic Dutch fitness centre that first opened 32 years ago has received an extensive overhaul following a vicious fire.
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Parkwood Leisure, one of the UK’s leading public leisure facilities operators, helped prevent more than 7,000 cases of stroke, dementia, depression and type 2 diabetes in 2019, saving the NHS £16 million, a new social value report has shown.
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Featured operator news: Everyone Active generates £342m in social value
Award-winning leisure operator Everyone Active generated £342million in social value at its sites across the country in 2019/20.
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Total Vibration Solutions / Floors 4 Gyms / TVS Sports Surfaces
Pendex
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Company profiles
Company profile: Keiser UK LTD
For more than four decades, Keiser has influenced the training of athletes, fitness enthusiasts and ...
Company profiles
Company profile: Technogym UK Ltd
Technogym offers a complete ecosystem of connected smart equipment, digital services, on-demand training experiences and ...
Catalogue Gallery
Click on a catalogue to view it online
Directory
Hydrotherapy / spa fragrances
Kemitron GmbH: Hydrotherapy / spa fragrances
Red Light Therapy
 Red Light Rising: Red Light Therapy
Architects/designers
Zynk Design Consultants: Architects/designers
Flooring
Total Vibration Solutions / TVS Sports Surfaces: Flooring
Management software
Premier Software Solutions: Management software
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trade associations
International SPA Association - iSPA: trade associations
Exercise equipment
Power Plate: Exercise equipment
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Himalayan Source: Salt therapy products
Lockers/interior design
Crown Sports Lockers: Lockers/interior design
Property & Tenders
Welwyn Garden City
Welwyn Hatfield Borough Council
Property & Tenders
Newport, Shropshire
Lilleshall Sports Academy
Property & Tenders
Diary dates
01-03 Feb 2022
Coventry Building Society Arena, Coventry, United Kingdom
Diary dates
07-10 Apr 2022
Exhibition Centre , Cologne, Germany
Diary dates
15-16 Jun 2022
ExCeL London, London, United Kingdom
Diary dates
01-07 Dec 2022
tbc, Dunedin, New Zealand
Diary dates
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